An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery disease.

Journal of Vascular Surgery
Christopher D OwensMichael S Conte

Abstract

Patients with advanced peripheral artery disease (PAD) have a high prevalence of cardiovascular (CV) risk factors and shortened life expectancy. However, CV risk factors poorly predict midterm (<5 years) mortality in this population. This study tested the hypothesis that baseline biochemical parameters would add clinically meaningful predictive information in patients undergoing lower extremity bypass operations. This was a prospective cohort study of patients with clinically advanced PAD undergoing lower extremity bypass surgery. The Cox proportional hazard model was used to assess the main outcome of all-cause mortality. A clinical model was constructed with known CV risk factors, and the incremental value of the addition of clinical chemistry, lipid assessment, and a panel of 11 inflammatory parameters was investigated using the C statistic, the integrated discrimination improvement index, and Akaike information criterion. The study monitored 225 patients for a median of 893 days (interquartile range, 539-1315 days). In this study, 50 patients (22.22%) died during the follow-up period. By life-table analysis (expressed as percent surviving ± standard error), survival at 1, 2, 3, 4, and 5 years, respectively, was 90.5% ± 1.9%...Continue Reading

References

Oct 18, 2000·Annals of Internal Medicine·D P Kotler
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Yves Ingenbleek, Vernon R Young
Jul 10, 2003·The Journal of Surgical Research·Ralph G DePalmaMark R Hall
Sep 27, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L DoweikE Minar
Jul 14, 2005·Journal of Vascular Surgery·Jamal BaraniAnders Gottsäter
Aug 10, 2005·American Heart Journal·Mary McGrae McDermottLuigi Ferrucci
Nov 23, 2006·Cytokine & Growth Factor Reviews·Amarjit SainiClaire E H Stewart
Jan 12, 2007·American Journal of Epidemiology·Nancy Swords JennyRussell P Tracy
Apr 29, 2008·Journal of Vascular Surgery·Christopher D OwensMichael S Conte
Nov 27, 2009·Journal of Vascular Surgery·Philip P GoodneyUNKNOWN Vascular Study Group Of Northern New England
May 18, 2010·Journal of Vascular Surgery·Michael H CriquiMary M McDermott

❮ Previous
Next ❯

Citations

May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge
May 13, 2017·Annals of Vascular Surgery·Lucie Salomon du MontSimon Rinckenbach
Nov 28, 2013·Journal of the American Heart Association·Douglas W JonesUNKNOWN Vascular Study Group of New England
Jul 10, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Bram KremersArina Ten Cate-Hoek
Oct 12, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Abel Arul NathanMadhulika Dixit
Jul 8, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyoshi AzumaHisashi Uchida
Dec 21, 2018·Journal of the American Heart Association·Adelaide M Arruda-OlsonHongfang Liu
Apr 8, 2021·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·A V GavrilenkoXiaochen Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.