An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival

Mathematical Biosciences and Engineering : MBE
Alexis B CookTrachette L Jackson

Abstract

Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery. Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. Here we present a multiscale modeling framework for investigating the synergism between traditional chemotherapy and targeted therapies aimed at critical regulators of apoptosis.

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Citations

Jun 6, 2018·Acta Crystallographica. Section C, Structural Chemistry·Binrong YaoKe Yan
Feb 12, 2020·Cancer Research·Fereshteh NazariTrachette L Jackson
Jun 28, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Michelle PrzedborskiMohammad Kohandel

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