An integrated console for capsule-based, automated organic synthesis.

Chemical Science
Tuo JiangJeffrey Bode

Abstract

The current laboratory practices of organic synthesis are labor intensive, impose safety and environmental hazards, and hamper the implementation of artificial intelligence guided drug discovery. Using a combination of reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions with prepacked capsules. The machine conducts coupling reactions and delivers the purified products with minimal user involvement. Two desirable reaction classes - the synthesis of saturated N-heterocycles and reductive amination - were implemented, along with multi-step sequences that provide drug-like organic molecules in a fully automated manner. We envision that this system will serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.

References

Oct 31, 2002·Nature Reviews. Drug Discovery·Steven V Ley, Ian R Baxendale
Oct 29, 2005·Nuclear Medicine and Biology·Seung Jun OhDae Hyuk Moon
Sep 2, 2006·Molecular Biotechnology·Muriel AmblardGilles Subra
Jan 5, 2010·Chemical & Pharmaceutical Bulletin·Kazuhiro MachidaTakashi Takahashi
Dec 9, 2014·Journal of the American Chemical Society·Woon-Yew Siau, Jeffrey W Bode
Jul 21, 2015·Angewandte Chemie·Steven V LeyRichard J Ingham
Mar 8, 2018·Angewandte Chemie·Melanie Trobe, Martin D Burke
Sep 22, 2018·Science·Anne-Catherine BédardTimothy F Jamison
Mar 9, 2019·Journal of the American Chemical Society·Fumito SaitoJeffrey W Bode
Apr 28, 2020·Journal of the American Chemical Society·A Abragam JosephPeter H Seeberger
Jul 19, 2020·Nature Communications·Alain C VaucherTeodoro Laino

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