PMID: 9657848Jul 10, 1998Paper

An integrated genetic linkage map of the laboratory rat

Mammalian Genome : Official Journal of the International Mammalian Genome Society
D M BrownH J Jacob

Abstract

The laboratory rat, Rattus novegicus, is a major model system for physiological and pathophysiological studies, and since 1966 more than 422,000 publications describe biological studies on the rat (NCBI/Medline). The rat is becoming an increasingly important genetic model for the study of specific diseases, as well as retaining its role as a major preclinical model system for pharmaceutical development. The initial genetic linkage map of the rat contained 432 genetic markers (Jacob et al. 1995) out of 1171 developed due to the relatively low polymorphism rate of the mapping cross used (SHR x BN) when compared to the interspecific crosses in the mouse. While the rat genome project continues to localize additional markers on the linkage map, and as of 11/97 more than 3,200 loci have been mapped. Current map construction is using two different crosses (SHRSP x BN and FHH x ACI) rather than the initial mapping cross. Consequently there is a need to provide integration among the different maps. We set out to develop an integrated map, as well as increase the number of markers on the rat genetic map. The crosses available for this analysis included the original mapping cross SHR x BN reciprocal F2 intercross (448 markers), a GH x BN ...Continue Reading

Citations

May 26, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Takahiro MurakamiKiyokazu Agata
Mar 29, 2001·Current Hypertension Reports·M Stoll, H J Jacob
Sep 5, 2002·Molecular Genetics and Metabolism·R R ChrissluisT R King
Nov 26, 1999·Current Opinion in Pulmonary Medicine·C G Tankersley
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Jan 22, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jane Kenney-HuntMichael R Felder
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Jul 19, 2003·Scandinavian Journal of Immunology·P Olofsson, R Holmdahl
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Jan 5, 2000·Physiological Reviews·J P Rapp
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Oct 9, 2003·Physiological Genomics·Carol MorenoAllen W Cowley

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