An integrated index combined by dynamic hyperinflation and exercise capacity in the prediction of morbidity and mortality in COPD

Respiratory Care
Eylem Sercan OzgürBahar Taşdelen

Abstract

Dynamic hyperinflation (DH) and exercise limitation develop in patients with COPD; however, there is lack of knowledge about their long-term clinical consequences. We aimed to assess the impact of DH and exercise capacity in predicting mortality and also morbidity, as evaluated by emergency visits and hospital admissions in COPD patients during a 4-year period. We recruited 73 stable COPD patients. The relationships of different respiratory parameters (FEV(1)%, body mass index, 6 min walk test distance [6MWD], static hyperinflation as measured by the ratio of inspiratory capacity to total lung capacity (IC/TLC) at rest, DH as measured by the change between the post- and pre-exercise values of IC/TLC [ΔIC/TLC], P(aO(2)), and P(aCO(2))) with emergency visits and hospital admissions because of exacerbations and also with respiratory and all-cause mortality were assessed. The median follow-up period was 47 months (IQR 45-48 months, n = 73). During the follow-up there were 8 (11%) deaths. The ΔIC/TLC value was 3.9 ± 4.6%. The Kaplan-Meier survival curve showed that the cumulative survival rate was significantly lower in the patients with ΔIC/TLC > 4 and with 6MWD ≤ 439.56 m, using these values as thresholds. (The rates for sensitivi...Continue Reading

Citations

Sep 14, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Kai M BeehAnton Drollmann
Jan 23, 2016·The European Respiratory Journal·Luis Puente-MaestuSusan Ward
Oct 20, 2020·Frontiers in Medicine·Kathryn M MilneDenis E O'Donnell

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