An integrated model of thermodynamic-hemodynamic-pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in brain hypothermia treatment

Journal of Theoretical Biology
Lu GaohuaHidenori Kimura

Abstract

Brain hypothermia treatment (BHT) is an intensive care characterized by simultaneous managements of various vital signs, such as intracranial temperature (ICT) and pressure (ICP), of the severe neuropatient. Medical treatments including therapeutic ambient cooling and diuresis are separately carried out based on the experience of the medical staff involved in the clinical management of various pathophysiological processes, such as thermodynamics, hemodynamics and pharmacokinetics. However, no special attention has been paid to the interactions among these subsystems in therapeutic hypothermia because of the lack of theoretical knowledge. Therefore, quantitative analyses using an integrated model of various physiological processes and their interactions are of pressing need. In the present paper, we propose a general compartmental model to describe the pathophysiological processes of the three aforementioned dynamics, on account of the dynamical analogy of temperature, pressure and concentration. The model is verified by the agreement of model-based simulation results with clinical evidence. Based on responses of the integrated model to various stimuli, a transfer function matrix is identified to linearly approximate the charact...Continue Reading

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Aug 16, 2005·Journal of Theoretical Biology·Lu Gaohua, Hidenori Kimura

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Citations

Nov 30, 2007·Theoretical Biology & Medical Modelling·Lu Gaohua, Hidenori Kimura
Dec 1, 2009·Theoretical Biology & Medical Modelling·Lu Gaohua, Hidenori Kimura
Dec 28, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yannick TholanceArmand Perret-Liaudet
Apr 9, 2008·IEEE Transactions on Bio-medical Engineering·Lu Gaohua, Hidenori Kimura
Apr 30, 2017·Research in Veterinary Science·Tomasz GrabowskiMarcin Świtała

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