An Integrated Neuronal Model of Claustral Function in Timing the Synchrony Between Cortical Areas

Frontiers in Neural Circuits
Trichur R Vidyasagar, Ekaterina Levichkina

Abstract

It has been suggested that the function of the claustrum (CL) may be to orchestrate and integrate the activity of the different cortical areas that are involved in a particular function by boosting the synchronized oscillations that occur between these areas. We propose here a model of how this may be done, thanks to the unique synaptic morphology of the CL and its excitatory and inhibitory connections with most cortical areas. Using serial visual search as an example, we describe how the functional anatomy of the claustral connections can potentially execute the sequential activation of the representations of objects that are being processed serially. We also propose that cross-frequency coupling (CFC) between low frequency signals from CL and higher frequency oscillations in the cortical areas will be an efficient means of CL modulating neural activity across multiple brain regions in synchrony. This model is applicable to the wide range of functions one performs, from simple object recognition to reading and writing, listening to or performing music, etc.

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Citations

Aug 1, 2020·Frontiers in Human Neuroscience·Kim ArcherTrichur Raman Vidyasagar
Jul 9, 2021·Behavioral and Brain Functions : BBF·Vladimir N NikolenkoGjumrakch Aliev

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