An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms-a tool for quantitative assessment of hydrogel formation processes

Journal of Pharmaceutical and Biomedical Analysis
Piotr KulinowskiWładysław P Węglarz

Abstract

Controlled release (CR) dosage forms are often based on polymeric matrices, e.g., sustained-release tablets and capsules. It is crucial to visualise and quantify processes of the hydrogel formation during the standard dissolution study. A method for imaging of CR, polymer-based dosage forms during dissolution study in vitro is presented. Imaging was performed in a non-invasive way by means of the magnetic resonance imaging (MRI). This study was designed to simulate in vivo conditions regarding temperature, volume, state and composition of dissolution media. Two formulations of hydrodynamically balanced systems (HBS) were chosen as model CR dosage forms. HBS release active substance in stomach while floating on the surface of the gastric content. Time evolutions of the diffusion region, hydrogel formation region and "dry core" region were obtained during a dissolution study of L-dopa as a model drug in two simulated gastric fluids (i.e. in fed and fasted state). This method seems to be a very promising tool for examining properties of new formulations of CR, polymer-based dosage forms or for comparison of generic and originator dosage forms before carrying out bioequivalence studies.

References

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·B J FahieA Blazek
Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·P ColomboN A Peppas
Dec 22, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·B N Singh, K H Kim
Mar 10, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·S HardingA Seo
Jul 8, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·C A FyfeB J Fahie
Sep 7, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·C A Fyfe, A I Blazek-Welsh
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jonathan C D SutchColin D Melia

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Citations

Oct 16, 2010·Journal of Pharmaceutical Sciences·G ShikoJ M Butler
May 18, 2012·Journal of Pharmaceutical Sciences·Zoe A LanghamStephen A C Wren
Nov 19, 2011·Drug Discovery Today·Przemysław P DorożyńskiGreg J Stanisz
Dec 1, 2010·International Journal of Pharmaceutics·M D Mantle
Mar 8, 2016·The Journal of Pediatrics·Emma NorrisEmmanuel Stamatakis
Jan 27, 2015·The British Journal of Nutrition·Trudy VoortmanEdith H van den Hooven
Feb 9, 2017·European Journal of Public Health·Vincent BuschMai J Chinapaw

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