An integrated system for genetic analysis.

BMC Bioinformatics
Simon FiddyRichard Mott

Abstract

Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use. We have developed an Integrated Genotyping System (IGS) to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward. IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site http://bioinformatics.well.ox.ac.uk/project-igs.shtml contains further information.

References

Sep 16, 1999·American Journal of Human Genetics·D Clayton, H Jones
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Apr 21, 2001·European Journal of Human Genetics : EJHG·G R AbecasisL R Cardon
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Jan 16, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·William S J ValdarRichard Mott
Sep 21, 2004·Bioinformatics·Lan-Juan ZhaoHong-Wen Deng

❮ Previous
Next ❯

Citations

Nov 13, 2008·European Journal of Human Genetics : EJHG·Inês SousaUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Apr 23, 2009·European Journal of Human Genetics : EJHG·Nuala H SykesUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
May 28, 2013·Nature Genetics·UNKNOWN Rat Genome Sequencing and Mapping ConsortiumJonathan Flint
Nov 6, 2010·Human Molecular Genetics·Thomas S ScerriAnthony P Monaco
May 13, 2009·BMC Bioinformatics·Sebastian SchönherrAnita Brandstätter
Aug 4, 2010·Molecular Autism·Inês SousaUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Sep 15, 2010·PLoS Genetics·Binnaz YalcinJonathan Flint
Nov 10, 2010·PloS One·Thomas S ScerriAlex J Richardson
Feb 18, 2015·Source Code for Biology and Medicine·Robert V BaronDaniel E Weeks
Jan 1, 2014·Scientific Data·Amelie BaudJonathan Flint

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

GIDS
BC
NET
CimSoft
Linux
NET Framework
SQL Server
Excel
Windows PC
SNPP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.