An integrated view of L-selectin and trophinin function in human embryo implantation.

The Journal of Obstetrics and Gynaecology Research
Michiko N Fukuda, Kazuhiro Sugihara

Abstract

Determining molecular mechanisms of human embryo implantation is an extremely challenging task due to the limitation of materials and significant differences underlying this process among mammalian species. Recently, L-selectin and its ligand carbohydrate have been proposed as a system that mediates initial adhesion of human blastocysts to the uterine epithelia. We have also identified trophinin as a unique apical cell adhesion molecule potentially involved in the initial adhesion of trophectoderm of the human blastocyst to endometrial surface epithelia. In the mouse, the binding between ErbB4 on the blastocyst and heparin-binding epidermal growth factor-like growth factor on the endometrial surface enables the initial step of the blastocyst implantation. The evidence suggests that L-selectin and trophinin are included in human embryo implantation. This review summarizes findings relevant to the functions of L-selectin and trophinin in human embryo implantation, and proposes a model that reconciles these cell adhesion mechanisms.

References

Dec 31, 1991·Biochemical and Biophysical Research Communications·T Yamagata, K Yamazaki
Mar 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·S Lindenberg
Jul 1, 1991·Journal of Reproduction and Fertility·J D Aplin
Aug 1, 1986·Developmental Biology·M IzharM N Fukuda
Sep 15, 1980·International Journal of Cancer. Journal International Du Cancer·P W AndrewsB B Knowles
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B C PariaS K Dey
Jul 1, 1994·Journal of Reproduction and Fertility·U Bentin-LeyT Horn
Jun 1, 1997·Molecular Human Reproduction·A LopataD M Robertson
Jun 12, 1998·Biology of Reproduction·M M DeSouzaD D Carson
Jun 11, 1999·The New England Journal of Medicine·A J WilcoxC R Weinberg
May 8, 2000·Seminars in Reproductive Endocrinology·C B Kirn-Safran, D D Carson
Jul 7, 2000·Developmental Biology·D D CarsonK Yoshinaga
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·J D Aplin
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·B C PariaB L Hogan

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Citations

Dec 28, 2012·The Journal of Biological Chemistry·Misa Suzuki-AnekojiMinoru Fukuda
Dec 1, 2012·Reproductive Biology and Endocrinology : RB&E·Seong Kyu ParkMichiko N Fukuda
Jul 16, 2013·International Journal of Molecular Sciences·Qing-Zhen XieJing Yang
May 21, 2009·Journal of Anatomy·Harmeet Singh, John D Aplin
Mar 31, 2011·Molecular Reproduction and Development·Laura LecceChristopher R Murphy
Apr 24, 2014·American Journal of Reproductive Immunology : AJRI·Koji Yoshinaga
Aug 26, 2014·TheScientificWorldJournal·Naguib Salleh, Nelli Giribabu
Jun 7, 2013·Biology of Reproduction·Kerri Stanley YipDavid J Waxman
May 16, 2014·Biology of Reproduction·Shuangdi LiJiarong Zhang
Oct 11, 2017·PloS One·Paula Quintero-RonderosPaul Laissue
May 27, 2009·Current Opinion in Obstetrics & Gynecology·Amy M Cline, William H Kutteh
Mar 14, 2020·International Journal of Molecular Sciences·Hiroshi FujiwaraYoshihiko Araki
Jan 4, 2017·Journal of Cell Science·John D Aplin, Peter T Ruane
Feb 19, 2021·Journal of Nanobiotechnology·Lewis W FrancisR Steven Conlan
May 22, 2009·Current Opinion in Obstetrics & Gynecology

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