An integrative approach for in silico glioma research.

IEEE Transactions on Bio-medical Engineering
Lee A D CooperJoel H Saltz

Abstract

The integration of imaging and genomic data is critical to forming a better understanding of disease. Large public datasets, such as The Cancer Genome Atlas, present a unique opportunity to integrate these complementary data types for in silico scientific research. In this letter, we focus on the aspect of pathology image analysis and illustrate the challenges associated with analyzing and integrating large-scale image datasets with molecular characterizations. We present an example study of diffuse glioma brain tumors, where the morphometric analysis of 81 million nuclei is integrated with clinically relevant transcriptomic and genomic characterizations of glioblastoma tumors. The preliminary results demonstrate the potential of combining morphometric and molecular characterizations for in silico research.

References

Sep 1, 1935·Proceedings of the National Academy of Sciences of the United States of America·E Fisher
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Feb 12, 2009·Molecular Cancer Research : MCR·Subha MadhavanKenneth Buetow

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Citations

Apr 20, 2013·Journal of Pathology Informatics·Fusheng WangJoel H Saltz
Jan 27, 2012·Journal of the American Medical Informatics Association : JAMIA·Lee A D CooperJoel H Saltz
Aug 21, 2013·Journal of the American Medical Informatics Association : JAMIA·Sonal KothariMay D Wang
Aug 17, 2011·Journal of Pathology Informatics·Fusheng WangJoel Saltz
Sep 29, 2011·IEEE Transactions on Bio-medical Engineering·Jun KongDaniel J Brat
Aug 1, 2013·The International Journal of High Performance Computing Applications·Joel SaltzTahsin Kurc
Jul 6, 2011·Nature Reviews. Neurology·Gregory Riddick, Howard A Fine
Jan 30, 2016·Science Advances·Dinorah Friedmann-MorvinskiInder M Verma
Jun 2, 2020·JCO Clinical Cancer Informatics·Ashish SharmaFred Prior
Feb 6, 2017·Archives of Pathology & Laboratory Medicine·Alton Brad FarrisGeoffrey H Smith
Feb 28, 2017·The International Journal of High Performance Computing Applications·George TeodoroJoel Saltz
Oct 23, 2018·Concurrency and Computation : Practice & Experience·Jeremias GomesGeorge Teodoro

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