An integrative bioinformatics analysis identified miR-375 as a candidate key regulator of malignant breast cancer

Journal of Applied Genetics
Jiaxuan LiuDaya Luo

Abstract

MicroRNAs (miRNAs) are key regulators that play important biological roles in carcinogenesis and are promising biomarkers for cancer diagnosis and therapy. hsa-miR-375-3p (miR-375) has been suggested to serve as a tumor suppressor or oncogene in various tumor types; however, its specific expression and potential regulatory role in malignant breast cancer remain unclear. In this study, the results from noncoding RNA microarray analysis indicated that the miR-375 expression level is significantly decreased in malignant basal-like breast cancer compared with luminal-like breast cancer. A total of 1895 co-downregulated and 1645 co-upregulated genes were identified in miR-375 mimic-transfected basal-like breast cancer cell lines. Predicted miR-375 targets were obtained from the online databases TargetScan and DIANA-microT-CDS. Combined KEGG enrichment analysis for coregulated genes and predicted miR-375 targets provided information and revealed differences in potential dynamic signaling pathways regulated by miR-375 and also indicated specific regulatory pathways, such as RNA transport and processing, in basal-like breast cancer. Additionally, gene expression microarray analysis accompanied by UALCAN analysis was performed to screen...Continue Reading

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Citations

Oct 29, 2020·Journal of Biochemical and Molecular Toxicology·Mohammed A Mansour
Nov 12, 2020·Cancers·Andrea AngiusMaria Rosaria De Miglio
Aug 2, 2020·European Journal of Pharmacology·Qiong ZhaoLufeng Zheng

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Datasets Mentioned

BETA
GSE19536
GSE40057
GSE40056

Software Mentioned

CDS
TargetScan
UALCAN
Partek Genomic Suites
Bioconductor
microT
GraphPad Prism7
TargetScan7
DIANA
GEO2R

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