An Integrative Breakage Model of genome architecture, reshuffling and evolution: The Integrative Breakage Model of genome evolution, a novel multidisciplinary hypothesis for the study of genome plasticity

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Marta FarréAurora Ruiz-Herrera

Abstract

Our understanding of genomic reorganization, the mechanics of genomic transmission to offspring during germ line formation, and how these structural changes contribute to the speciation process, and genetic disease is far from complete. Earlier attempts to understand the mechanism(s) and constraints that govern genome remodeling suffered from being too narrowly focused, and failed to provide a unified and encompassing view of how genomes are organized and regulated inside cells. Here, we propose a new multidisciplinary Integrative Breakage Model for the study of genome evolution. The analysis of the high-level structural organization of genomes (nucleome), together with the functional constrains that accompany genome reshuffling, provide insights into the origin and plasticity of genome organization that may assist with the detection and isolation of therapeutic targets for the treatment of complex human disorders.

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Citations

Apr 1, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ignacio Maeso
May 18, 2016·Genome Biology and Evolution·Priscila BillerEric Tannier
Feb 6, 2017·Genome Biology and Evolution·Cibele G Sotero-CaioDavid A Ray
Mar 3, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Rafael D AcemelJosé Luis Gómez-Skarmeta
Nov 15, 2016·Current Opinion in Genetics & Development·Ignacio MaesoJosé Luis Gómez-Skarmeta
Feb 9, 2018·Genes·Janine E Deakin
Jan 12, 2019·Reproduction, Fertility, and Development·Janine E Deakin, Sally Potter
Dec 12, 2019·Annual Review of Animal Biosciences·Janine E Deakin, Rachel J O'Neill
Apr 8, 2020·Genes·Sergey MatveevskyIrina Bakloushinskaya
Aug 23, 2019·Genes·Janine E DeakinTariq Ezaz
Sep 13, 2019·International Journal of Molecular Sciences·Svetlana A RomanenkoIrina Bakloushinskaya
May 22, 2021·Nature Communications·Covadonga VaraAurora Ruiz-Herrera

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