An Intelligent Graphene-Based Biosensing Device for Cytokine Storm Syndrome Biomarkers Detection in Human Biofluids.

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Zhuang HaoShaoqin Liu

Abstract

Abnormal elevated levels of cytokines such as interferon (IFN), interleukin (IL), and tumor necrosis factor (TNF), are considered as one of the prognosis biomarkers for indicating the progression to severe or critical COVID-19. Hence, it is of great significance to develop devices for monitoring their levels in COVID-19 patients, and thus enabling detecting COVID-19 patients that are worsening and to treat them before they become critically ill. Here, an intelligent aptameric dual channel graphene-TWEEN 80 field effect transistor (DGTFET) biosensing device for on-site detection of IFN-γ, TNF-α, and IL-6 within 7 min with limits of detection (LODs) of 476 × 10-15 , 608 × 10-15 , or 611 × 10-15 m respectively in biofluids is presented. Using the customized Android App together with this intelligent device, asymptomatic or mild COVID-19 patients can have a preliminary self-detection of cytokines and get a warning reminder while the condition starts to deteriorate. Also, the device can be fabricated on flexible substrates toward wearable applications for moderate or even critical COVID-19 cases for consistently monitoring cytokines under different deformations. Hence, the intelligent aptameric DGTFET biosensing device is promising ...Continue Reading

References

Dec 7, 2010·Journal of the American Chemical Society·Yasuhide OhnoKazuhiko Matsumoto
Apr 29, 2015·Biosensors & Bioelectronics·Cheng WangQiao Lin
Apr 29, 2015·Biosensors & Bioelectronics·Sidra FaridMichael A Stroscio
Jan 6, 2016·Advanced Materials·Houk JangJong-Hyun Ahn
Nov 30, 2016·Advanced Materials·Wangyang FuGrégory F Schneider
Aug 5, 2017·ACS Applied Materials & Interfaces·Zhuang HaoQiao Lin
Oct 28, 2017·Science Advances·Wangyang FuHans-Joachim Krause
May 17, 2018·Nano Letters·Yibo ZhuJames C Hone
Nov 13, 2019·Nature Nanotechnology·Jonathan Sabaté Del RíoDonald E Ingber
Mar 29, 2020·The Journal of Clinical Investigation·Savannah F Pedersen, Ya-Chi Ho
Apr 16, 2020·Arthritis & Rheumatology·Lauren A HendersonPeter A Nigrovic
Apr 19, 2020·Science·John B Moore, Carl H June
Jun 3, 2020·ACS Sensors·Steven M RussellRoberto de la Rica
Jun 10, 2020·Nature Medicine·Aaron J WilkCatherine A Blish
Aug 17, 2020·Signal Transduction and Targeted Therapy·Fan ZhangZhiwei Huang
Sep 17, 2020·Science Advances·Minjae KuJang-Ung Park
Oct 2, 2020·Science Advances·Yu SongWei Gao

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