An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social-emotional mediators.

Development and Psychopathology
Amy L ByrdStephanie D Stepp

Abstract

Early threat exposure is a transdiagnostic risk factor for psychopathology, and evidence suggests that genetic variation in the oxytocin receptor (OXTR) moderates this association. However, it is unclear if this gene-by-environment (G×E) interaction is tied to unique risk for disorder-specific outcomes or instead increases shared risk for general psychopathology. Moreover, little is known about how this G×E interaction increases risk. The current study utilized a prospective, longitudinal sample of females (n = 2,020) to examine: (a) whether the interaction between early threat exposure and OXTR variation (rs53576, rs2254298) confers risk for disorder-specific outcomes (depression, anxiety, borderline and antisocial personality disorders) and/or general psychopathology in early adulthood; and (b) whether social-emotional deficits (emotion dysregulation, callousness, attachment quality) during adolescence constitute mediating mechanisms. Consistent with hypotheses, the interactive effects of early threat exposure and OXTR variation (rs53576) predicted general psychopathology, with threat-exposed women carrying at least one copy of the rs53576 A-allele at greatest risk. This interaction was mediated via emotional dysregulation in...Continue Reading

References

Jul 13, 1999·Archives of General Psychiatry·J G JohnsonD P Bernstein
Dec 3, 1999·Journal of Abnormal Child Psychology·P J FrickP Silverthorn
Aug 15, 2001·Journal of Clinical Child Psychology·E B FoaK R Treadwell
Nov 2, 2001·Journal of Health Care for the Poor and Underserved·K D Frick, J Regan
Apr 4, 2002·Psychological Methods·Robert C MacCallumDerek D Rucker
Apr 4, 2002·Psychological Methods·Roderick P McDonald, Moon-Ho Ringo Ho
Oct 3, 2002·Criminal Behaviour and Mental Health : CBMH·Alison E HipwellLeoniek Kroneman
Feb 22, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Dustin A PardiniPaul J Frick
May 7, 2003·Neuroscience and Biobehavioral Reviews·Martin H TeicherDennis M Kim
Sep 5, 2003·Physiology & Behavior·C Sue Carter
Oct 16, 2003·JAMA : the Journal of the American Medical Association·E Jane CostelloAdrian Angold
Mar 3, 2004·Journal of Abnormal Psychology·Sara R JaffeeAlan Taylor
Jan 26, 2005·Trends in Cognitive Sciences·Laurence Steinberg
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Jun 24, 2005·Development and Psychopathology·Sara R JaffeeLucy A Tully
Nov 29, 2005·European Archives of Psychiatry and Clinical Neuroscience·Robert F AndaWayne H Giles
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sarah-Jayne Blakemore, Suparna Choudhury
Apr 15, 2006·Development and Psychopathology·Fred A Rogosch, Dante Cicchetti
Aug 1, 2006·Hormones and Behavior·Amanda R Tarullo, Megan R Gunnar
Dec 22, 2006·Developmental Science·Michael Rutter
Jul 31, 2007·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Alison E HipwellMagda Stouthamer-Loeber
Aug 25, 2007·Annual Review of Clinical Psychology·Robert F Krueger, Kristian E Markon
Aug 25, 2007·Annual Review of Clinical Psychology·Dante Cicchetti, Sheree L Toth
Jan 29, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Paul J Frick, Stuart F White
Apr 11, 2008·Annals of the New York Academy of Sciences·B J CaseyTodd A Hare
Jul 17, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review
Jun 24, 2009·Developmental Neuroscience·C Sue CarterKaren L Bales
Sep 26, 2009·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Kenneth A Dodge
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sarina M RodriguesDacher Keltner
Jan 7, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jungmeen Kim, Dante Cicchetti
Jun 26, 2010·Development and Psychopathology·Ann S Masten, Dante Cicchetti
Aug 26, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sara R Jaffee, Andrea Kohn Maikovich-Fong
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Ronald C KesslerDavid R Williams
Jan 26, 2011·Development and Psychopathology·Marian J Bakermans-Kranenburg, Marinus H van Ijzendoorn
Feb 9, 2011·Archives of General Psychiatry·Benjamin B LaheyPaul J Rathouz
Jul 2, 2011·Behaviour Research and Therapy·Katie A McLaughlinSusan Nolen-Hoeksema

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