PMID: 29763DOI: 10.1016/0014-2999(78)90063-8Sep 1, 1978

An interaction of histamine H2-receptor antagonists with the noradrenergic system in rat brain

European Journal of Pharmacology
J Z NowakC Maslinski

Abstract

Intraventricular administration of 50 microgram of burimamide or 250 microgram of either metiamide or cimetidine decreased the NA concentration in rat hypothalamus by nearly 30%. Cimetidine did not significantly influence either DA or DOPAC levels in striatum. Cimetidine and metiamide significantly potentiated locomotor activity of tranylcypromine-treated rats and this effect was antagonized by phentolamine. It is concluded that the three histamine H2-receptor antagonists released NA in rat brain.

References

The pressor activity of burimamide: a relationship between chemical constitution and pressor activity of burimamide and related histamine H2-receptor antagonists

Mar 1, 1977·Agents and Actions·C R Ganellin, D A Owen

Effect of histamine H2-receptor antagonists on delayed hypersensitivity

Mar 25, 1978·Lancet·J AvellaP W Askenase

Rapid concurrent automated fluorimetric assay of noradrenaline, dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 3-methoxytyramine in milligram amounts of nervous tissue after isolation on Sephadex G10

Oct 1, 1977·Journal of Neurochemistry·B H Westerink, J Korf

Regional rat brain levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid: concurrent fluorometric measurement and influence of drugs

Aug 1, 1976·European Journal of Pharmacology·B H Westerink, J Korf

Does burimamide inhibit gastric acid secretion by a release of catecholamines?

Oct 22, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·M Albinus, K R Sewing

Metiamide--an orally active histamine H2-receptor antagonist

Oct 1, 1973·Agents and Actions·J W BlackJ H Wyllie

Cardiovascular effects of burimamide and metiamide

Oct 1, 1974·Agents and Actions·M Albinus, K R Sewing

Definition and antagonism of histamine H 2 -receptors

Apr 21, 1972·Nature·J W BlackE M Parsons

Citations

Differences in presynaptic alpha-blockade, noradrenaline uptake inhibition, and potential antidepressant activity between (+)- and (-)mianserin

Jan 1, 1981·Psychopharmacology·H SchoemakerV J Nickolson

Influence of the H2-receptor blocking agent metiamide on the clonidine-induced changes in the brain catecholamine turnover

Jan 1, 1980·Journal of Neural Transmission·N E Andén, M Grabowska-Andén

Effects of the histamine H2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system

Apr 1, 1980·Agents and Actions·J Z NowakC Maslinski

Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat

Apr 1, 1988·Agents and Actions·C NettiA Pecile

Interaction of histamine H2-receptor blocking drugs with the noradrenergic system in rat brain and heart

Nov 7, 1980·European Journal of Pharmacology·J Z Nowak

Cellular localization and possible functions for brain histamine: recent progress

Jan 1, 1988·Progress in Neurobiology·L B Hough

The effects of H1- and H2-receptor blocking agents on postsynaptic potentials recorded from the bull-frog sympathetic ganglion

Sep 1, 1988·Pharmacology & Toxicology·K TasakaC Kamei

Prediction of morphine dose in humans

Jan 4, 2012·Paediatric Anaesthesia·Nick H G HolfordBrian J Anderson

Differences between the measured and calculated free serum phenytoin concentrations in epileptic patients

Sep 1, 2009·Yonsei Medical Journal·Ji-Man HongWon-Joo Kim

High and variable population prevalence of HLA-B*56:02 in indigenous Australians and relation to phenytoin-associated drug reaction with eosinophilia and systemic symptoms

Jun 18, 2019·British Journal of Clinical Pharmacology·Andrew A SomogyiGenevieve M Gabb

Indirect sympathomimetic effect of some H2-histamine receptor antagonists in the isolated uterus of the rat

Nov 1, 1982·The Journal of Pharmacy and Pharmacology·E RubioJ Esplugues

Related Concepts

Metazoa
Brain
Burimamide
Tagamet
Intropin
Histamine H2 Antagonists
Metiamide Monohydrochloride
Norepinephrine, (+, -)-Isomer
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt
Rats, Laboratory

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

ContactHelpTerms Privacy Cookies Blog
© 2021 Meta ULC. All rights reserved