An interaction study with cimetidine and the new angiotensin II antagonist valsartan

European Journal of Clinical Pharmacology
E K SchmidtA Racine-Poon

Abstract

This was a randomised, open, three-way crossover study in 12 healthy male volunteers to determine the effect of a single oral dose of cimetidine on the pharmacokinetics of a single oral dose of the angiotensin II receptor antagonist valsartan and vice versa. The volunteers received either valsartan alone (160 mg), or cimetidine alone (800 mg), or valsartan 1 h after cimetidine. The study was designed primarily to detect a possible influence of cimetidine on the rate and extent of absorption of valsartan. Plasma concentrations of valsartan and cimetidine, measured by means of high-performance liquid chromatography, were used to calculate pharmacokinetic parameters. The rate of absorption of valsartan and the fraction of the dose absorbed and systemically available after oral administration were calculated using data from an i.v. study with valsartan in healthy young volunteers. The pharmacokinetics of cimetidine area under curve (AUC0-48 h), maximum concentration (Cmax), time to reach Cmax(tmax) and apparent terminal plasma half-life (t1/2) was not changed by co-administration of valsartan. For valsartan, the AUC0-48 h increased by 7% and the Cmax by 51% (ratio of geometric means) with co-administration of cimetidine. The higher...Continue Reading

Citations

Sep 13, 2008·Archives of Pharmacal Research·Zong-Zhu PiaoBeom-Jin Lee
May 20, 2003·CNS Drugs·Leah M HesseDavid J Greenblatt
Apr 5, 2012·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Ritesh N Sharma, Shyam Sunder Pancholi
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P A Thürmann
Feb 16, 2005·Expert Opinion on Drug Safety·Steffen BöhlerWilhelm Kirch
Jul 5, 2005·Expert Opinion on Investigational Drugs·A Chioléro, M Burnier
Mar 16, 2007·Current Medical Research and Opinion·Gangadhar SunkaraPratapa Prasad
Aug 24, 2010·International Journal of Pharmaceutics·Yi-Dong YanHan Gon Choi
Jul 17, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Thomas Unger, Elena Kaschina
Oct 7, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tom T G NieskensAnna-Karin Sjögren
Aug 8, 2021·Journal of Pharmaceutical Sciences·James Butler, Patrick Augustijns

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