An interactive genome browser of association results from the UK10K cohorts project

Bioinformatics
Matthias GeihsNicole Soranzo

Abstract

High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort individuals were analysed for statistical associations with 64 different phenotypic traits of biomedical importance. Here, we describe a novel genome browser based on the Biodalliance platform developed to provide interactive access to the association results of the project. The browser is available at http://www.uk10k.org/dalliance.html. Source code for the Biodalliance platform is available under a BSD license from http://github.com/dasmoth/dalliance, and for the LD-display plugin and backend from http://github.com/dasmoth/ldserv.

References

Jul 20, 2010·Bioinformatics·W J KentD Karolchik
Jan 22, 2011·Bioinformatics·Thomas A DownTim J P Hubbard
Mar 9, 2012·Nature Biotechnology·David AdamsSpike Willcocks
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Feb 20, 2015·Nature·UNKNOWN Roadmap Epigenomics ConsortiumManolis Kellis
Sep 15, 2015·Nature·UNKNOWN UK10K ConsortiumNicole Soranzo

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Citations

Oct 6, 2016·Frontiers in Immunology·Samira AsgariUNKNOWN Swiss Pediatric Sepsis Study
Dec 13, 2016·Nucleic Acids Research·Chen SunChaochun Wei
Sep 15, 2015·Nature·UNKNOWN UK10K ConsortiumNicole Soranzo
Oct 8, 2015·Nature Reviews. Genetics·Magdalena Skipper

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Software Mentioned

genome browser
UK10K Genome Browser
UK10K
Biodalliance renderer
Biodalliance
bigBed
bigWig

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