An interdisciplinary review of the thanatomicrobiome in human decomposition

Forensic Science, Medicine, and Pathology
Gulnaz T JavanDeEtta Mills


Death does not occur instantaneously and organs do not decompose at the same rate or in the same way. Nulligravid human uteri and prostate glands are the last internal organs to deteriorate during decomposition; however, the reason for this very important observation is still enigmatic. Recent studies have elucidated that the composition and abundance of microbes in the human thanatomicrobiome (microbiome of death) varies by organ and changes as a function of time and temperature. The ileocecal area has the largest absolute postmortem burden that spreads to the liver and spleen and continues to the heart and brain depending on the cause of death. To truly understand the mechanisms of microbial assembly during decomposition, a thorough examination of different strategies utilized by the trillions of microbes that colonize decaying tissues is needed from a multi-organ and multidisciplinary approach. In this review, we highlight interdisciplinary research and provide an overview of human decomposition investigations of thanatomicrobiomic changes in internal organs.


Aug 1, 1975·Forensic Science·W Gevers
Oct 1, 1988·Forensic Science International : Synergy·W BärW Schmid
Apr 16, 1998·The American Journal of Forensic Medicine and Pathology·N R Di NunnoM Melato
Apr 4, 2000·Physiological Reviews·K J Ellis
Jul 18, 2001·Forensic Science International : Synergy·C P Campobasso, F Introna
Dec 6, 2001·Brain Research. Brain Research Protocols·K YasojimaP L McGeer
May 29, 2002·Brain Research·Stacey A TrotterJames P Bennett
Apr 16, 2003·Journal of Neurochemistry·Matthew R HyndPeter R Dodd
Jun 6, 2003·Current Opinion in Genetics & Development·Cheng HuangCornelius F Boerkoel
Nov 30, 2004·Forensic Science International : Synergy·Marija DurićDanijela Donić
Oct 10, 2006·Journal of Bioscience and Bioengineering·Yasunori SuzukiKunihiko Watanabe
May 24, 2008·Reproductive Sciences·Katherine Chang, Lubo Zhang
Jun 26, 2009·Experimental & Applied Acarology·M Lee Goff
Jan 11, 2011·Journal of Forensic and Legal Medicine·Chong Zhou, Roger W Byard
Feb 8, 2011·Trends in Ecology & Evolution·Erin E Wilson, Elizabeth M Wolkovich
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Christine H LeeAlexander Kirschenbaum
Dec 21, 2011·The American Journal of Forensic Medicine and Pathology·D Kimberley Molina, Vincent J M DiMaio
Feb 14, 2012·Journal of Hepatology·Derrick E FoutsBernd Schnabl
Jun 5, 2012·Journal of Bacteriology·Eric J Stewart
Jun 14, 2012·Nature Communications·Mathilde LatilFabrice Chrétien
Apr 2, 2013·Journal of Medical Entomology·M Eric BenbowJennifer L Pechal
Apr 5, 2013·Journal of Forensic Sciences·Sari TuomistoTanja Pessi
Jun 12, 2013·International Journal of Legal Medicine·Jennifer L PechalJeffery K Tomberlin
Nov 23, 2013·PloS One·Jennifer L PechalM Eric Benbow
Feb 4, 2014·International Journal of Legal Medicine·Szymon MatuszewskiMichał Szafałowicz
Aug 6, 2014·Journal of Microbiological Methods·Ismail CanPeter A Noble
Nov 29, 2014·International Journal of Legal Medicine·Embriette R HydeSibyl R Bucheli
Mar 27, 2015·Journal of Forensic Sciences·Franklin E DamannAlice C Layton
Apr 22, 2015·The American Journal of Forensic Medicine and Pathology·Teddric WilliamsGulnaz T Javan
Jul 11, 2015·The American Journal of Forensic Medicine and Pathology·D Kimberley Molina, Vincent J M DiMaio
Mar 5, 2016·Frontiers in Microbiology·Gulnaz T JavanJennifer G Mulle
Apr 2, 2016·Forensic Science International : Synergy·Z M BurchamH R Jordan
Jul 15, 2016·Scientific Reports·Gulnaz T JavanAaron M Tarone
May 18, 2017·Forensic Science International : Synergy·Ayodeji O OlakanyeT Komang Ralebitso-Senior
May 21, 2017·Journal of Forensic and Legal Medicine·Torri B ThomasGulnaz T Javan
Jun 20, 2017·PeerJ·Jennifer M DeBruyn, Kathleen A Hauther
Mar 29, 2013·Clinical Liver Disease·Lena Sibulesky


Oct 2, 2020·Applied Microbiology and Biotechnology·Hirak Ranjan Dash, Surajit Das
Apr 22, 2020·Scientific Reports·Gulnaz T JavanJack Ballantyne
Nov 26, 2020·International Journal of Legal Medicine·Ann-Sofie CeciliasonHåkan Sandler
Dec 29, 2020·Frontiers in Microbiology·Holly LutzGulnaz T Javan
Feb 2, 2021·Frontiers in Microbiology·Jake M RobinsonEran Elhaik

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