An interdisciplinary review of the thanatomicrobiome in human decomposition

Forensic Science, Medicine, and Pathology
Gulnaz T JavanDeEtta Mills

Abstract

Death does not occur instantaneously and organs do not decompose at the same rate or in the same way. Nulligravid human uteri and prostate glands are the last internal organs to deteriorate during decomposition; however, the reason for this very important observation is still enigmatic. Recent studies have elucidated that the composition and abundance of microbes in the human thanatomicrobiome (microbiome of death) varies by organ and changes as a function of time and temperature. The ileocecal area has the largest absolute postmortem burden that spreads to the liver and spleen and continues to the heart and brain depending on the cause of death. To truly understand the mechanisms of microbial assembly during decomposition, a thorough examination of different strategies utilized by the trillions of microbes that colonize decaying tissues is needed from a multi-organ and multidisciplinary approach. In this review, we highlight interdisciplinary research and provide an overview of human decomposition investigations of thanatomicrobiomic changes in internal organs.

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Citations

Oct 2, 2020·Applied Microbiology and Biotechnology·Hirak Ranjan Dash, Surajit Das
Apr 22, 2020·Scientific Reports·Gulnaz T JavanJack Ballantyne
Nov 26, 2020·International Journal of Legal Medicine·Ann-Sofie CeciliasonHåkan Sandler
Dec 29, 2020·Frontiers in Microbiology·Holly LutzGulnaz T Javan
Feb 2, 2021·Frontiers in Microbiology·Jake M RobinsonEran Elhaik

Related Concepts

Brain
Heart
Liver
Myocardium
Livor Mortis
Prostate
Spleen
Uterus
Bacterial Physiological Phenomena
Bacterial Translocation

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