An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism

Science
Pin WangXuetao Cao

Abstract

Viruses regulate host metabolic networks to improve their survival. The molecules that are responsive to viral infection and regulate such metabolic changes are hardly known, but are essential for understanding viral infection. Here we identify a long noncoding RNA (lncRNA) that is induced by multiple viruses, but not by type I interferon (IFN-I), and facilitates viral replication in mouse and human cells. In vivo deficiency of lncRNA-ACOD1 (a lncRNA identified by its nearest coding gene Acod1, aconitate decarboxylase 1) significantly attenuates viral infection through IFN-I-IRF3 (interferon regulatory factor 3)-independent pathways. Cytoplasmic lncRNA-ACOD1 directly binds the metabolic enzyme glutamic-oxaloacetic transaminase (GOT2) near the substrate niche, enhancing its catalytic activity. Recombinant GOT2 protein and its metabolites could rescue viral replication upon lncRNA-ACOD1 deficiency and increase lethality. This work reveals a feedback mechanism of virus-induced lncRNA-mediated metabolic promotion of viral infection and a potential target for developing broad-acting antiviral therapeutics.

References

Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L ZhouP D Berk
Jun 12, 2012·Molecular Cell·Alexander G BaltzMarkus Landthaler
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alessandro MichelucciKarsten Hiller
Oct 15, 2013·Archives of Biochemistry and Biophysics·Michael D Toney
Dec 18, 2013·Science·Ophir ShalemFeng Zhang
Dec 24, 2013·Nature Reviews. Immunology·Lionel B Ivashkiv, Laura T Donlin
Apr 30, 2014·Nature Reviews. Genetics·Kevin V Morris, John S Mattick
Aug 13, 2014·Trends in Immunology·James A Heward, Mark A Lindsay
Nov 22, 2014·Frontiers in Immunology·Elena CarneroPuri Fortes
Mar 31, 2015·Virology·Erica L Sanchez, Michael Lagunoff
Apr 7, 2015·Cell·Ci ChuHoward Y Chang
Oct 7, 2015·Trends in Microbiology·Christopher M GoodwinJoshua Munger
Oct 11, 2015·Virus Research·Puri Fortes, Kevin V Morris
Nov 2, 2015·Trends in Endocrinology and Metabolism : TEM·Alfredo CastelloThomas Preiss
Apr 2, 2016·Science·Ainara Castellanos-RubioSankar Ghosh
Jun 18, 2016·Cell·Maninjay K AtianandKatherine A Fitzgerald
Jul 28, 2016·Molecular Cell·Alfredo CastelloMatthias W Hentze
Aug 1, 2016·Current Opinion in Virology·Megan H PowdrillJohn Paul Pezacki
Aug 16, 2016·Nature·Jonathan J KotzinJorge Henao-Mejia
Sep 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hironori NishitsujiKunitada Shimotohno
Nov 20, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre L LévyBirke Bartosch
Jan 14, 2017·Cell·Daniel A BoseShelley L Berger
Jan 14, 2017·Cell·Qian ZhangDavid Baltimore
Mar 1, 2017·Current Opinion in Cell Biology·Jeroen Rpm Strating, Frank Jm van Kuppeveld

❮ Previous
Next ❯

Citations

Dec 14, 2017·Frontiers in Immunology·Xing-Yu MengHua-Ji Qiu
Nov 25, 2017·Science·Jonathan J KotzinJorge Henao-Mejia
Jun 23, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Sadhan DasRama Natarajan
Dec 1, 2018·Molecular Oncology·Nerina DenaroCristiana Lo Nigro
Jan 17, 2019·Non-coding RNA·Nkerorema Djodji DamasTroels K H Scheel
Jan 8, 2019·Journal of Zhejiang University. Science. B·Pei-Fen FuAi-Fu Lin
Mar 29, 2019·Nature Reviews. Immunology·Qian Zhang, Xuetao Cao
Mar 29, 2019·The EMBO Journal·Qiong ZhangTariq M Rana
Jan 12, 2020·In Vitro Cellular & Developmental Biology. Animal·Zhenhua Yang, Tianjun Hu
Feb 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaobo ChangGaiping Zhang
Dec 15, 2017·Nature·Nicholas S Heaton, Bryan R Cullen
Jun 17, 2020·Emerging Microbes & Infections·Jing Wang, Shan Cen
Jun 23, 2020·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
Jun 24, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah C PyfromJacqueline E Payton
Apr 17, 2018·Non-coding RNA·Amanda Salviano-SilvaMaria Luiza Petzl-Erler
Apr 25, 2019·Reviews in Medical Virology·Shaoqiong LiuWeifeng Shi
Jul 25, 2019·Cell Research·Ganes C Sen, Bryan R G Williams
Feb 11, 2020·Frontiers in Cellular and Infection Microbiology·Federica AglianoAndrei E Medvedev
Jan 6, 2019·Molecular Neurobiology·Silvia ZucchelliStefano Gustincich
Aug 15, 2018·Viruses·Tarryn BourhillRandal N Johnston
Jun 19, 2019·Nature Immunology·Smita KulkarniMary Carrington
Feb 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Kenneth StapletonRama Natarajan
Sep 25, 2018·Frontiers in Immunology·Veron RamsuranSmita Kulkarni
Sep 25, 2018·Nucleic Acids Research·Zhaolong LiWenyan Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.