An internal ribosome entry segment in the 5' untranslated region of the mnt gene

Oncogene
M StoneleyS C Wright

Abstract

Mnt is a transcriptional repressor related to the Myc/Mad family of transcription factors. It is expressed in proliferating, resting and differentiating cells and is believed to antagonize the function of Myc. Here we have characterized the major transcription initiation site of the mnt gene. In doing so we noted a remarkable level of sequence conservation between the murine and human 5' untranslated regions. Our experiments revealed that this sequence contains an internal ribosome entry segment (IRES). In addition, we show that sequences at both the 5' and 3' end of the IRES are essential for its function. These findings indicate that mnt can be translated by internal initiation. Such a mechanism may allow efficient Mnt synthesis when cap-dependent translation initiation is reduced.

References

Jan 1, 1995·Current Topics in Microbiology and Immunology·N IizukaP Sarnow
May 1, 1994·Molecular Biology Reports·R J JacksonA Kaminski
Nov 20, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N Schreiber-Agus, R A DePinho
Jan 19, 1999·Annual Review of Cell and Developmental Biology·N K Gray, M Wickens
Nov 13, 1999·Nature Cell Biology·M HolcikR G Korneluk
Jan 29, 2000·Molecular and Cellular Biology·M StoneleyA E Willis
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A ChappellV P Mauro

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Citations

Nov 17, 2001·Molecular and Cellular Biology·R SchneiderM Wormington
Sep 8, 2006·RNA·Stephen D BairdMartin Holcik
Mar 12, 2009·Biology of the Cell·Sangeeta Chatterjee, Jayanta K Pal
Feb 16, 2002·Clinical Genetics·B A Oostra, P Chiurazzi

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