An international multicenter study evaluating the impact of an alternative biochemical failure definition on the judgment of prostate cancer risk

International Journal of Radiation Oncology, Biology, Physics
Scott G WilliamsSandra Turner

Abstract

To evaluate the impact of an alternative biochemical failure (bF) definition on the performance of existing plus de novo prognostic models. The outcomes data of 1,458 Australian and 703 Canadian men treated with external-beam radiation monotherapy between 1993 and 1997 were analyzed using a lowest prostate-specific antigen (PSA) level to date plus 2 ng/mL (L + 2) bF definition. Two existing prognostic models were scrutinized using discrimination (Somers Dxy [SDxy]) and calibration indices. Alternative prognostic models were also created using recursive partitioning analysis (RPA) and multivariate nomogram methods for comparison. Discrimination of bF was improved using the L + 2 definition compared with the American Society for Therapeutic Radiology and Oncology (ASTRO) definition using both the three-level risk model (SDxy 0.30 and 0.22, respectively) or the nomogram (SDxy 0.35 and 0.27, respectively). Both existing prognostic models showed only modest calibration accuracy. Using RPA, five distinct risk groups were identified based primarily on Gleason score (GS) and all subsequent divisions based on PSA. All GS 7-10 tumors were intermediate or high risk. This model and the developed nomogram showed improved discrimination over...Continue Reading

References

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Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Scott G Williams

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Citations

Dec 26, 2006·International Journal of Radiation Oncology, Biology, Physics·Tom Pickles, Scott G Williams
Sep 13, 2012·Acta Oncologica·Alexandru Dasu, Iuliana Toma-Dasu
Jan 24, 2007·Clinical Genitourinary Cancer·Padraig WardeRobert Bristow
Nov 7, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A ToledanoP Sèbe
Nov 13, 2007·International Journal of Radiation Oncology, Biology, Physics·Patrick A KupelianArul Mahadevan
Sep 24, 2013·BJU International·Matthieu DurandXavier Cathelineau
Nov 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Jiayi HuangLarry L Kestin
Nov 16, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·George RodriguesUNKNOWN Genitourinary Radiation Oncologists of Canada (GUROC)

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