An international perspective on anticholinergic therapy

The American Journal of Medicine
K R Chapman

Abstract

Since the introduction of inhaled quaternary anticholinergic bronchodilators, their clinical usefulness has been explored in a variety of settings. They have emerged as the inhaled bronchodilators of first choice in the management of chronic obstructive pulmonary disease (COPD). In other countries, they have also found an adjunctive role in the management of asthma. This may be best seen in the treatment of acute asthma where the combination of anticholinergic and adrenergic bronchodilators appear more effective than single-agent inhalation therapy. This finding appears consistently in large studies, whether in adult or pediatric populations. Such combination nebulizer therapy would appear to be cost effective, but further study is required.

References

Feb 1, 1977·The Journal of Allergy and Clinical Immunology·R E RuffinA S Rebuck
Jul 1, 1978·British Journal of Diseases of the Chest·I M LightbodyR N Johnston
Oct 1, 1985·British Journal of Diseases of the Chest·M J WardD Davies
Aug 25, 1988·The New England Journal of Medicine·N J Gross
Mar 1, 1983·The Journal of Allergy and Clinical Immunology·A S RebuckK R Chapman
Apr 1, 1983·British Journal of Diseases of the Chest·B C LeahyS C Allen
Feb 21, 1981·British Medical Journal·M J WardD Davies
Sep 23, 1993·The New England Journal of Medicine·R Matz
Apr 8, 1993·The New England Journal of Medicine·G T Ferguson, R M Cherniack

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Citations

Sep 28, 2013·Paediatric Respiratory Reviews·Benedict Griffiths, Francine M Ducharme
Apr 16, 2015·Journal of Paediatrics and Child Health·Colin Ve Powell, Noel E Cranswick
Sep 16, 1998·Journal of Gastroenterology and Hepatology·R H Hunt, S K Lam
Aug 15, 2003·The Cochrane Database of Systematic Reviews·N J McDonald, A I Bara
Mar 23, 2002·Paediatric Drugs·Benjamin Volovitz, Moshe Nussinovitch
Aug 24, 2013·The Cochrane Database of Systematic Reviews·Benedict Griffiths, Francine M Ducharme
Jan 15, 2000·Journal of Clinical Gastroenterology·M PerryA F Cutler
Apr 25, 2001·Journal of Clinical Gastroenterology·Y UstündağB Bilezikçi
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Laurie H Plotnick, Francine M Ducharme

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