An interparticle relatively motional DNA walker and its sensing application.

Chemical Science
Hong ZhangWei Jiang

Abstract

DNA molecular machines are DNA self-assemblies that perform quasi-mechanical movement at the micro-nano scale, and have attracted increasing attention in the fields of biosensing, drug delivery and biocomputing. Herein, we report the concept and operation of an interparticle relatively motional DNA walker. The walker is composed of walking particles (WPs) and track particles (TPs). The WPs and TPs are obtained by respective functionalization of locked walking strands containing DNAzyme sequences and fluorophore-labelled track strands containing substrate sequences onto gold nanoparticles (AuNPs). Triggered by the target that specifically unlocks the walking strand, the liberated walking strands cooperatively hybridize with the track strands. The track strand gets cleaved by the DNAzyme, accompanied by the fluorophore release. The adjacent walking strand on the WP subsequently hybridizes to the next track strand, inducing the relative motion of the WP around the TP. After walking along the surface of one TP, the WP can continue to interact with another TP. As a result of the improved moving freedom and area, the interparticle motional mode induces high continuity and achieves large signal accumulation. Taking Zika virus RNA frag...Continue Reading

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Citations

Sep 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ling HuXiao-Bing Zhang
May 20, 2021·Luminescence : the Journal of Biological and Chemical Luminescence·Yuling JiangXiandeng Hou

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Methods Mentioned

BETA
biosensing
electrophoresis
Fluorescence
dynamic light scattering

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