An Interplay between Obesity and Inflammation in Gestational Diabetes Mellitus

Current Pharmaceutical Biotechnology
Katarzyna E Skórzyńska-DziduszkoTeresa Małecka-Massalska

Abstract

Gestational diabetes mellitus (GDM) is traditionally defined as hyperglycemia first detected in pregnancy. The risk of GDM is much higher among obese women than in their lean counterparts. An excess of adipose tissue leads to immune and inflammatory responses of both white adipose tissue and the placenta, contributing to systemic inflammation. Although the significance of both obesity and inflammation is relatively well characterized in GDM, the molecular mechanisms involved are not fully defined and require further study. In recent years huge progress has been made in identifying the intracellular signaling pathways involved in the pathophysiology of GDM. However, currently available data regarding inflammation and obesity in women with GDM are still conflicting or incomplete. We discuss selected aspects of the problem and propose future directions for research in the hope of achieving a better understanding of the disease. In particular, this review highlights recent studies exploring molecular alterations related to insulin resistance, inflammation of the adipose tissue and the placenta, lipotoxicity or endotoxemia.

Citations

Oct 3, 2018·International Journal of Molecular Sciences·Żaneta Kimber-TrojnarBożena Leszczyńska-Gorzelak
Mar 29, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Anna WnukDariusz Szukiewicz
Apr 18, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nitin ShivappaBahram Rashidkhani
Oct 7, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Xinying QiXuezhen Wang
May 1, 2021·Antioxidants·Antonio SchiattarellaGianluca Rizzo

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