An Intervention Target for Myocardial Fibrosis: Autophagy

BioMed Research International
Chunmiao LuJunping Zhang

Abstract

Myocardial fibrosis (MF) is the result of metabolic imbalance of collagen synthesis and metabolism, which is widespread in various cardiovascular diseases. Autophagy is a lysosomal degradation pathway which is highly conserved. In recent years, research on autophagy has been increasing and the researchers have also become cumulatively aware of the specified association between autophagy and MF. This review highlights the role of autophagy in MF and the potential effects through the administration of medicine.

References

Dec 2, 2008·Acta Physiologica·A DanielsF A van Nieuwenhoven
Nov 15, 2011·Cellular and Molecular Life Sciences : CMLS·Wen-wen LiJin-ku Bao
May 9, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Toshinori AoyagiTakashi Matsui
May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis
May 10, 2013·The Journal of Biological Chemistry·Xianmin XuQiangrong Liang
Jun 6, 2013·Aging Cell·James M FlynnSimon Melov
Jul 19, 2013·Biochemical Society Transactions·Elaine A Dunlop, Andrew R Tee
Dec 25, 2013·Cell Research·Yuchen FengDaniel J Klionsky
Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Feb 11, 2014·European Journal of Pharmacology·Ming-Hui LiShao-Liang Chen
Feb 12, 2014·Journal of Molecular and Cellular Cardiology·Changhan OuyangZhonglin Xie
Jul 8, 2014·Acta Pharmacologica Sinica·Li-qing WengYun-zeng Zou
Aug 19, 2014·Oxidative Medicine and Cellular Longevity·Yoshiyuki IkedaJunichi Sadoshima
Oct 29, 2014·Nature Reviews. Cardiology·Bharath Ambale-Venkatesh, João A C Lima
Dec 17, 2014·Scientific Reports·Qi YuanGuangju Ji
Dec 30, 2014·Journal of Molecular and Cellular Cardiology·Phyllis-Jean LintonRoberta A Gottlieb
Jan 31, 2015·Circulation Research·Damián GaticaDaniel J Klionsky
Apr 24, 2015·American Journal of Hypertension·Xin ZhangLilach O Lerman
Jul 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lei LiuLina Wang
Aug 1, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wei WangZhuo Zhao
Nov 10, 2015·Molecular Medicine Reports·Huikuan GaoYongquan Wu
Dec 23, 2015·Frontiers in Biology·Deanna H MorrisQing Jun Wang
Apr 10, 2016·Journal of Molecular Biology·Daniel Papinski, Claudine Kraft
Apr 15, 2016·International Journal of Medical Sciences·Chao-Hung LaiChih-Yang Huang
Apr 26, 2016·Oxidative Medicine and Cellular Longevity·Shenglan LinLi Liu
May 14, 2016·Circulation Research·Akihiro ShirakabeJunichi Sadoshima
May 14, 2016·Circulation Research·Hiroyuki NakayamaKinya Otsu
Jun 6, 2016·Journal of Molecular and Cellular Cardiology·Ippei Shimizu, Tohru Minamino
Jun 12, 2016·The Journal of Nutritional Biochemistry·Rafael Oliveira FernandesAdriane Belló-Klein
Aug 22, 2016·Biochemical and Biophysical Research Communications·Guoran LiXianxian Zhao

❮ Previous
Next ❯

Citations

Jan 18, 2020·BioMed Research International·Xue YangDian Gao
Oct 17, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Shyam S NandiKaushik P Patel
Oct 7, 2020·Pharmacology & Therapeutics·Qirong LuMaría-Aránzazu Martínez
Dec 1, 2020·Frontiers in Physiology·Xue KongWei Ge
Mar 2, 2021·American Journal of Physiology. Renal Physiology·Lipeng ChenBenkang Shi

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
GTPase
transgenic

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms