Abstract
The intricate interactions between neurons, glial, and inflammatory cells within peripheral ganglia are physiologically important, but not well explored. Here, we show that adult dorsal root ganglia (DRG) contain populations of self-renewing cells, collectively referred as DRG resident cycling cells (DRCCs), that are active not only in "quiescent" ganglia but also accelerate their turnover in response to distal axotomy. An unexpected proportion of DRCCs were resident macrophages. These cells closely accompanied, and aligned with recycling satellite glial cells (SGCs) that were juxtaposed to sensory neurons and possessed stem cell-like properties. Selective inhibition of colony stimulating factor 1 receptor prevented the local proliferation of macrophages. Interestingly, DRCC turnover was accompanied by apoptosis at later intervals indicating a balanced cellular milieu in the DRGs. These findings identify a complex interactive multicellular DRG microenvironment supporting self-renewal of both macrophages and SGCs and its potential implications in the overall response of adult DRGs to injury.
References
Dec 6, 2001·The American Journal of Pathology·M MuellerR Kiefer
Feb 11, 2004·Experimental Neurology·Ping Hu, Elspeth M McLachlan
Jan 18, 2006·Journal of Neuropathology and Experimental Neurology·Tie ZouHouyan Song
Dec 17, 2009·Molecular Pain·David Vega-AvelairaMaria Fitzgerald
Feb 10, 2010·Journal of Neuropathology and Experimental Neurology·Yuk Shan ChenSookja K Chung
Sep 28, 2010·Cell·Simona ParrinelloAlison C Lloyd
May 14, 2011·Science·Stephen J JenkinsJudith E Allen
Jun 10, 2011·Glia·Christine A WebberDouglas W Zochodne
Apr 4, 2012·Brain, Behavior, and Immunity·SeungHwan Lee, Ji Zhang
Apr 11, 2013·Science Signaling·Anand Krishnan
Apr 23, 2013·Immunity·Daigo HashimotoMiriam Merad
Aug 13, 2013·Nature Medicine·Clinton S RobbinsFilip K Swirski
Sep 24, 2013·Nature Medicine·Stephanie M PyonteckJohanna A Joyce
Oct 15, 2013·Glia·Macayla DoneganPeter T Ohara
Apr 23, 2014·Nature Communications·Kimberly J ChristieDouglas Zochodne
Aug 19, 2014·Neuron·Antje KronerSamuel David
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Sep 24, 2014·PloS One·Diana Sofia Marques NascimentoFani Lourença Moreira Neto
May 17, 2015·Molecular and Cellular Neurosciences·Kimberly ChristieDouglas W Zochodne
Jun 28, 2015·Biochemical and Biophysical Research Communications·Taro KoikeHisao Yamada
Jul 16, 2015·The European Journal of Neuroscience·Anand KrishnanDouglas W Zochodne
Dec 8, 2015·Nature Neuroscience·Zhonghui GuanAllan I Basbaum
May 5, 2016·Acta Neuropathologica Communications·Arnulf H KoeppenJoseph E Mazurkiewicz
Jun 29, 2016·Nature Communications·Jiyun PengLong-Jun Wu
Apr 11, 2017·Journal of Neuropathology and Experimental Neurology·Jian-Qiang LuDonald W Gross
Citations
Feb 12, 2020·Glia·Sara E JagerChristian B Vaegter
Jul 14, 2020·Frontiers in Cellular Neuroscience·Bilal El WalyFranck Debarbieux
Apr 27, 2019·Frontiers in Cellular Neuroscience·Arul DuraikannuDouglas W Zochodne
Jun 2, 2020·Frontiers in Oncology·Maricris Bautista, Anand Krishnan
Oct 22, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Liya Y Qiao, Namrata Tiwari
Jan 4, 2021·Stem Cell Reviews and Reports·Dongyan WangHuanxiang Zhang
Nov 29, 2020·Molecular and Cellular Neurosciences·Anand KrishnanDouglas W Zochodne
Jan 10, 2020·Neuroscience·Myung-Chul NohPeter A Smith
Feb 18, 2021·European Journal of Pharmacology·Xiaoqing WangYufang Leng
Nov 17, 2020·Brain, Behavior, and Immunity·Li ZhangJun-Ming Zhang
Aug 28, 2021·Biomedicines·Kjeld Morten MohrChristian Bjerggaard Vaegter
Oct 15, 2021·Journal of Neuroinflammation·Haruki IwaiTetsuya Goto
Sep 8, 2021·The Journal of Clinical Investigation·Mithilesh Kumar JhaBrett M Morrison
Dec 9, 2021·Journal of Cellular and Molecular Medicine·Bei HuangEva Leitzen