An intimately bonded titanate nanotube-polyaniline-gold nanoparticle ternary composite as a scaffold for electrochemical enzyme biosensors

Analytica Chimica Acta
Xiaoqiang LiuDanny K Y Wong

Abstract

In this work, titanate nanotubes (TNTs), polyaniline (PANI) and gold nanoparticles (GNPs) were assembled to form a ternary composite, which was then applied on an electrode as a scaffold of an electrochemical enzyme biosensor. The scaffold was constructed by oxidatively polymerising aniline to produce an emeraldine salt of PANI on TNTs, followed by gold nanoparticle deposition. A novel aspect of this scaffold lies in the use of the emeraldine salt of PANI as a molecular wire between TNTs and GNPs. Using horseradish peroxidase (HRP) as a model enzyme, voltammetric results demonstrated that direct electron transfer of HRP was achieved at both TNT-PANI and TNT-PANI-GNP-modified electrodes. More significantly, the catalytic reduction current of H2O2 by HRP was ∼75% enhanced at the TNT-PANI-GNP-modified electrode, compared to that at the TNT-PANI-modified electrode. The heterogeneous electron transfer rate constant of HRP was found to be ∼3 times larger at the TNT-PANI-GNP-modified electrode than that at the TNT-PANI-modified electrode. Based on chronoamperometric detection of H2O2, a linear range from 1 to 1200 μM, a sensitivity of 22.7 μA mM(-1) and a detection limit of 0.13 μM were obtained at the TNT-PANI-GNP-modified electrode....Continue Reading

References

Jun 21, 2005·Journal of Colloid and Interface Science·Jin-Zhong XuHong-Yuan Chen
Dec 30, 2006·Analytical Chemistry·Jeremy M FowlerDanny K Y Wong
Jan 1, 2010·ACS Nano·Hao ZhangJinghong Li
Oct 25, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Anish RajanDaizy Philip

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