An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory

Journal of Computational Neuroscience
Christopher P Fall, John Rinzel

Abstract

We have developed a firing rate network model for working memory that combines Mexican-hat-like synaptic coupling with intrinsic or cellular dynamics that are conditionally bistable. While our approach is in the spirit of Camperi and Wang (1998) we include a specific and plausible mechanism for the cellular bistability. Modulatory neurotransmitters are known to activate second messenger signaling systems, and our model includes an intracellular Ca(2+) handling subsystem whose dynamics depend upon the level of the second messenger inositol 1,4,5 trisphosphate (IP3). This Ca(2+) subsystem endows individual units with conditional intrinsic bistability for a range of IP3. The full "hybrid" network sustains IP3-dependent persistent ("bump") activity in response to a brief transient stimulus. The bump response in our hybrid model, like that of Camperi-Wang, is resistant to noise-- its position does not drift with time.

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Citations

Mar 30, 2013·Journal of Computational Neuroscience·Eduardo Conde-Sousa, Paulo Aguiar
Dec 2, 2011·Cognitive Neurodynamics·Lina LiangZhikang Zhang
Mar 21, 2007·Nature Neuroscience·Emre AksayDavid W Tank
Aug 5, 2011·PloS One·Tatiana MalashchenkoGennady Cymbalyuk
Feb 13, 2016·Frontiers in Human Neuroscience·Yating ZhuYihong Wang
Apr 10, 2013·Neural Networks : the Official Journal of the International Neural Network Society·Vladimir P Zhdanov
Jul 29, 2009·Neural Networks : the Official Journal of the International Neural Network Society·Reinoud Maex, Volker Steuber
Sep 5, 2006·Journal of Computational Neuroscience·D A French, E I Gruenstein
Dec 12, 2012·Scientific Reports·Addolorata MarascoMichele Migliore
May 30, 2008·Journal of Neurophysiology·Esther I Krook-MagnusonMolly M Huntsman
Feb 23, 2011·Journal of Computational Neuroscience·Sherry-Ann BrownLeslie M Loew

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