An Intracellular Pathogen Response Pathway Promotes Proteostasis in C. elegans

Current Biology : CB
Kirthi C ReddyEmily R Troemel

Abstract

Maintenance of protein homeostasis, or proteostasis, is crucial for organismal health. Disruption of proteostasis can lead to the accumulation of protein aggregates, which are associated with aging and many human diseases such as Alzheimer's disease [1-3]. Through analysis of the C. elegans host response to intracellular infection, we describe here a novel response pathway that enhances proteostasis capacity and appears to act in parallel to well-studied proteostasis pathways. These findings are based on analysis of the transcriptional response to infection by the intracellular pathogen Nematocida parisii [4]. The response to N. parisii is strikingly similar to the response to infection by the Orsay virus, another natural intracellular pathogen of C. elegans, and is distinct from responses to extracellular pathogen infection [4-6]. We have therefore named this common transcriptional response the intracellular pathogen response (IPR), and it includes upregulation of several predicted ubiquitin ligase complex components such as the cullin cul-6. Through a forward genetic screen we found pals-22, a gene of previously unknown function, to be a repressor of the cul-6/cullin gene and other IPR gene expression. Interestingly, pals-22 ...Continue Reading

Citations

Aug 5, 2020·Cellular Microbiology·Hala Tamim El Jarkass, Aaron W Reinke
Aug 23, 2019·Journal of Virology·Lise FrézalMarie-Anne Félix
Mar 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Johan PanekEmily R Troemel
Sep 6, 2020·Molecular Genetics and Genomics : MGG·Jogender Singh
Nov 16, 2020·The FEBS Journal·Vladimir Lažetić, Emily R Troemel
Jul 16, 2019·Trends in Biochemical Sciences·Jay MilesPatricija van Oosten-Hawle
Jan 14, 2021·Cell Reports·Michael K FasseasMichalis Barkoulas
Feb 26, 2021·Cellular and Molecular Life Sciences : CMLS·Juan A Garcia-SanchezOrane Visvikis
Apr 7, 2021·Nature Ecology & Evolution·Daehan LeeErik C Andersen
Sep 18, 2021·Molecular Ecology·Lisa van SluijsJan E Kammenga
Oct 9, 2021·Biochemical Society Transactions·Benjamin W Harding, Jonathan J Ewbank
Nov 2, 2021·Frontiers in Cellular and Infection Microbiology·Manish GroverMichalis Barkoulas

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