Oct 31, 2019

An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

The Journal of Infectious Diseases
Joan B GeisbertKarla A Fenton

Abstract

Due to the difficulty in conducting clinical trials for vaccines and treatments against Nipah virus (NiV), licensure will likely require animal models, most importantly non-human primates (NHPs). The NHP models of infection have primarily relied on intratracheal instillation or small particle aerosolization of NiV. However, neither of these routes adequately models natural mucosal exposure to NiV. To develop a more natural NHP model, we challenged African green monkeys with the Bangladesh strain of NiV by the intranasal route using the laryngeal mask airway (LMA) mucosal atomization device (MAD). LMA MAD exposure resulted in uniformly lethal disease that accurately reflected the human condition.

  • References15
  • Citations2

Citations

Mentioned in this Paper

Nipah Virus
Nonhuman primate
Vaccines
poly(lauryl methacrylate)
Anesthesia, Intratracheal
Intranasal Approach
Intubating Laryngeal Mask Airway
Monkeys
Clinical Trials
Black African

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