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An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

The Journal of Infectious Diseases

Oct 30, 2019

Thomas W GeisbertKarla A Fenton

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Abstract

Due to the difficulty in conducting clinical trials for vaccines and treatments against Nipah virus (NiV), licensure will likely require animal models, most importantly nonhuman primates (NHPs). The NHP models of infection have primarily relied on intratracheal instillation or small par...read more

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Anesthesia, Intratracheal
Clinical Trials
Monkeys
Vaccines
Nonhuman primate
Black African
Intranasal Approach
Nipah Virus
poly(lauryl methacrylate)
Intubating Laryngeal Mask Airway
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An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

The Journal of Infectious Diseases

Oct 30, 2019

Thomas W GeisbertKarla A Fenton

PMID: 31665362

DOI: 10.1093/infdis/jiz391

Abstract

Due to the difficulty in conducting clinical trials for vaccines and treatments against Nipah virus (NiV), licensure will likely require animal models, most importantly nonhuman primates (NHPs). The NHP models of infection have primarily relied on intratracheal instillation or small par...read more

Mentioned in this Paper

Anesthesia, Intratracheal
Clinical Trials
Monkeys
Vaccines
Nonhuman primate

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