An intravascular large B-cell lymphoma with a t(3;14)(q27;q32) translocation

Journal of Clinical Pathology
Jing CuiQing Sun

Abstract

A 61-year-old man with no symptom was found with bilateral adrenal nodules on CT scan during a routine physical check-up. The left nodule was removed by adrenalectomy, and the patient was diagnosed with intravascular large B-cell lymphoma (IVLBCL) on pathological and immunohistochemical examinations. Using a set of dual-colour, break-apart probes and fluorescence in situ hybridisation, it was revealed that the lymphoma cells have tetraploid karyotype, with a breakpoint in BCL6 gene, which was further confirmed as a t(3;14)(q27;q32) translocation. To the best of our knowledge, this is the first report of IVLBCL with such a translocation.

References

Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Haytham KhouryDouglas E Horsman
Sep 22, 2009·Journal of the American Academy of Dermatology·Maymi KatoKenji Kabashima
Sep 17, 2011·Internal Medicine·Taishi Kobayashi, Hitoshi Ohno

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Citations

Aug 25, 2016·International Journal of Surgical Pathology·Jianchao WangWenyan Zhang
Mar 24, 2018·International Journal of Surgical Pathology·Yevgeniy LinnikXiaoying Liu
May 6, 2017·Virchows Archiv : an International Journal of Pathology·Yevgeniy LinnikXiaoying Liu

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