PMID: 8960124Aug 1, 1996Paper

An intronic polymorphic repeat sequence modulates interleukin-1 alpha gene regulation

Molecular Immunology
S BaillyG W Duff

Abstract

Recently, we characterized a polymorphism within IL-1 alpha intron 6 as a variable number of a 46 bp tandem repeat (ranging from 5 to 18 repeats). We now analyse whether this polymorphism could play a role in IL-1 alpha gene regulation. We have found that reporter gene expression driven by the IL-1 alpha promoter or a heterologous promoter was decreased by increasing numbers of the repeat sequence corresponding to the most frequent alleles seen in the human population. Furthermore, we showed that the transcription factor Sp1 can bind to the 46 bp sequence. Finally, we were unable to show a statistically-significant relation between in vitro IL-1 alpha production and the number of repeats although there was a clear trend towards an inverse relation. Taken together, these results are consistent with a negative regulatory role for IL-1 alpha intron 6 repeat sequence on IL-1 alpha basal gene transcription.

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Citations

Sep 6, 2005·Nature Genetics·Yeong-Gwan ParkKent W Hunter
Mar 13, 2003·Kidney International·Jeannette T BensenDonald W Bowden
Dec 7, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hanna BesslerLea Sirota
Jan 25, 2003·The British Journal of Ophthalmology·T AungR A Hitchings
Oct 7, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Hind BerrahmouneSophie Visvikis-Siest
Nov 13, 2008·Tissue Antigens·K A MarkeyG R Hill
Jul 16, 2005·Leukemia & Lymphoma·Hannah Cullup, Gail Stark
Jun 11, 1998·The Journal of Biological Chemistry·J PaquetteC Deal
Aug 2, 2008·Biochemical and Biophysical Research Communications·So-Young SeolSun-Hee Leem

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