An invasive marker Staphylococcus epidermidis surface protein I (SesI) harboured by a ST239 methicillin-resistant Staphylococcus aureus

Journal of Global Antimicrobial Resistance
Yamuna Devi BakthavatchalamBalaji Veeraraghavan

Abstract

Recently, the virulence factor sasX was described on the mobile genetic element φSPβ prophage in a ST239-SCCmecIII methicillin-resistant Staphylococcus aureus (MRSA) clone. The aim of this study was to identify sesI, an sasX homologue, in an MRSA ST239 strain. MRSA strain VB1490 was isolated from a patient with MRSA bacteraemia in India. Staphylococcal cassette chromosomemec (SCCmec) typing and whole-genome shotgun sequencing were performed. Phylogenetic analysis of VB1490 and ST239 reference genomes from the NCBI database was performed. Amplification and sequencing of the sasX gene was performed to establish allele homology. The sasX gene identified in isolate VB1490 was more similar to the sesI gene of Staphylococcus epidermidis RP62A than the sasX gene of ST239 MRSA strain. Whole-genome analysis revealed the presence of the sasX gene on a φSPβ-like prophage that exhibited high sequence identity to that of S. epidermidis strain RP62A. These finding suggests the dissemination of the invasion-determining virulence factorsesI from S. epidermidis to a ST239 MRSA strain.

Citations

Dec 13, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Silvestre Ortega-PeñaJuan Carlos Cancino-Diaz

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