An Inverse Dose Optimization Algorithm for Three-Dimensional Brachytherapy

Frontiers in Oncology
Xianliang WangJie Li

Abstract

To investigate an implementation method and the results of an inverse dose optimization algorithm, Gradient Based Planning Optimization (GBPO), for three-dimensional brachytherapy. The GBPO used a quadratic objective function, and a dwell time modulation item was added to the objective function to restrict the dwell time variance. We retrospectively studied 4 cervical cancer patients using different applicators and 15 cervical cancer patients using the Fletcher applicator. We assessed the plan quality of GBPO by isodose lines for the patients using different applicators. For the 15 patients using the Fletcher applicator, we utilized dose-volume histogram (DVH) parameters of HR-CTV (D100%, V150%) and organs at risk (OARs) (D0.1cc, D1cc, D2cc) to evaluate the difference between the GBPO plans and the IPSA (Inverse Planning Simulated Annealing) plans, as well as the GBPO plans and the Graphic plans. For the 4 patients using different applicators, the dose distributions are conformable. For the 15 patients using the Fletcher applicator, when the dwell time modulation factor (DTMF) is less than 20, the dwell time deviation reduces quickly; however, after the DTMF increased to 100, the dwell time deviation has no remarkable change. T...Continue Reading

References

Sep 25, 2007·International Journal of Radiation Oncology, Biology, Physics·Enrique ChajonChristine Haie-Meder
Feb 11, 2012·Medical Physics·Asa HolmAsa Carlsson Tedgren
Dec 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christian KirisitsFrank-André Siebert
Dec 8, 2014·Australasian Physical & Engineering Sciences in Medicine·Ryan L SmithJeremy L Millar
Dec 31, 2014·Physics in Medicine and Biology·Marleen BalvertAswin L Hoffmann
Sep 18, 2016·Advanced Drug Delivery Reviews·Kari TanderupRichard Pötter
Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Alexandru NicolaeAnanth Ravi
Sep 19, 2018·Physics in Medicine and Biology·Songye CuiLuc Beaulieu
Nov 28, 2018·Journal of Contemporary Brachytherapy·Xianliang WangQing Hou

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

HIPO
SPSS
MPI
CUDA Compute Unified Device Architecture )
LBFGS Shanno
IPSA Simulated
Graphic
GBPO
IPSA

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