An Inverse U-Shaped Curve of Resting-State Networks in Individuals at High Risk of Alzheimer's Disease

The Journal of Clinical Psychiatry
Qing YeFeng Bai

Abstract

Higher functional connectivity (FC) in resting-state networks has been shown in individuals at risk of Alzheimer's disease (AD) by many studies. However, the longitudinal trajectories of the FC remain unknown. The present 35-month follow-up study aimed to explore longitudinal changes in higher FC in multiple resting-state networks in subjects with the apolipoprotein E ε4 allele (ApoE4) and/or amnestic mild cognitive impairment (aMCI). Fifty-one subjects with aMCI and 64 cognitively normal (CN) subjects underwent neuropsychological tests and resting-state functional magnetic resonance imaging (fMRI) scans twice from April 2011 to June 2015. Subjects were divided into 4 groups according to diagnosis and ApoE4 status. The CN non-ApoE4 group served as a control group, and other groups served as AD risk groups. The cross-sectional and longitudinal patterns of multiple resting-state networks, including default mode network, hippocampus network, executive control network, and salience network, were explored by comparing FC data between groups and between time points, respectively. At baseline, compared with the control group, the AD risk groups showed higher FC with 8 regions in multiple networks. At follow-up, 6 of the regions displa...Continue Reading

Citations

Mar 11, 2020·Alzheimer's Research & Therapy·Raymond P Viviano, Jessica S Damoiseaux
Dec 24, 2018·Frontiers in Psychiatry·Li LinYing Han
Jul 13, 2021·Journal of Alzheimer's Disease : JAD·Shanshan ChenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 14, 2021·CNS Neuroscience & Therapeutics·Feifei ZangUNKNOWN Alzheimer’s Disease Neuroimaging Initiative*

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