An investigation and pathological analysis of two fatal cases of cadmium poisoning

Forensic Science International : Synergy
Yun-feng ChangYa-dong Guo

Abstract

Pollution associated with population growth, and with industrial and urban development has led to a serious decline in the water quality of Chinese rivers. Cadmium (Cd) is recognized as one of the most toxic metals and is strongly accumulated by organisms. Humans are exposed to cadmium originating from the environment and from industrial pollution. In spite of thousands of published studies on Cd, there is little information on its pathological features seen in human autopsy. The gross and pathological findings of forensic autopsies of two case of cadmium poisoning are presented and related to an epidemiological investigation. In both cases, multiple organ damage was observed, involving brain, lung, liver, kidney, red blood cells, and platelets, which is consistent with reports in the literature. In particular, in both cases, transmission electron microscopy revealed a large number of dense lysosomal and phagocytic particles in the cytoplasm near the nucleus, indicating the need for a genotoxic study of cadmium. Our observations provide new clues for the future recognition and prevention of Cd poisoning.

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Citations

Jun 12, 2013·Lancet·Hon-Ming LamSamuel Sai-Ming Sun
Apr 6, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hayato BabaJohji Imura
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wylly Ramsés García-Niño, José Pedraza-Chaverrí
Nov 17, 2017·International Journal of Environmental Research and Public Health·Jorge Retamal-SalgadoIván Matus
Sep 15, 2018·Journal of Applied Toxicology : JAT·Magdalena Mężyńska, Malgorzata M Brzóska

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