An investigation concerning tumor cell antigenicity of hamster malignant melanoma utilizing heterologous antiserum

Journal of Oral Pathology
S Gulmen


The antigenic potential of spontaneous malignant melanoma of the Syrian hamster was investigated. Antisera to the tumor were prepared in two groups of rabbits; one group was immunized with tumor homogenate material and the other with tissue cultured tumor cells. The antiserum was absorbed with normal hamster tissue extracts and serum to remove cross-reacting antibodies. The presence of tumor specific antibodies was demonstrated using immunodiffusion and fluorescent antibody staining techniques. Tumor specific antiserum prepared in this manner gave a single precipitin line against tumor tissue in gel-diffusion tests, and showed specific staining of tumor cells in the fluorescent antibody test.


Jan 1, 1973·Advances in Cancer Research·J H KerseyR A Good
Aug 1, 1966·The Journal of Investigative Dermatology·A W KopfN S Cooper
Nov 1, 1969·Transplantation·G A VoisinC Bernard
Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·G KleinJ Stjernswärd
Jun 1, 1970·Cancer·W W SutowK M Griffith
Sep 1, 1969·Archives of Surgery·S H Nadler, G E Moore
Nov 1, 1965·Experimental Cell Research·J KahnD M Robinson
Jun 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·M GOKCEN


Jan 1, 1985·Toxicologic Pathology·R L RobisonF H Ballard

Related Concepts

Tumor Antigens
Immunofluorescence Assay
Immunodiffusion Measurement
Immune Sera
Neoplasms, Experimental

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.