An investigation into the digestion of chitosan (noncrosslinked and crosslinked) by human colonic bacteria

Journal of Pharmaceutical Sciences
Emma L McConnellAbdul W Basit

Abstract

Chitosan salts are being investigated as materials for bacterially triggered colonic drug delivery, via the oral route, based on the assumption that they will be degraded by the enzymes produced by the human colonic bacteria. The actual susceptibility of chitosan to these enzymes is, however, unclear. The digestion of chitosan films (noncrosslinked, and crosslinked with glutaraldehyde or tripolyphosphate) by human colonic bacteria (using human faecal material) was therefore investigated, and in addition, their digestion by pancreatic enzymes (of porcine origin) was assessed. Noncrosslinked chitosan films were digested by both pancreatic and colonic enzymes within 4 h, while glutaraldehyde crosslinked chitosan films were resistant to both enzyme systems. In contrast, tripolyphosphate crosslinked chitosan films resisted pancreatic digestion, but were susceptible to faecal digestion over the same 4 h time period. As expected, lowering crosslinker concentration and increasing incubation time (to 18 h) allowed greater digestion. The difference between the crosslinkers is attributed to the mechanism of crosslinking, and the associated degree of film swelling in an aqueous environment. Swelling studies in acidic conditions suggest tha...Continue Reading

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Citations

Dec 15, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hamed LarouiDidier Merlin
Jun 27, 2009·Journal of Drug Targeting·Emma L McConnellAbdul W Basit
Nov 19, 2008·Journal of Drug Targeting·Abdul W BasitEmma L McConnell
Jul 11, 2013·Journal of Pharmaceutical Sciences·Valeria AraujoCristián Tapia
Aug 6, 2009·Journal of Pharmaceutical Sciences·He WeiCao De-Ying
Feb 5, 2011·International Journal of Pharmaceutics·Wanwisa KhunawattanakulThaned Pongjanyakul
Nov 26, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·He WeiCao De-Ying
Jul 22, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emma L McConnellAbdul W Basit
Jul 8, 2008·International Journal of Pharmaceutics·Emma L McConnellAbdul W Basit
Dec 4, 2012·International Journal of Pharmaceutics·Wycliffe S OmwanchaSteven H Neau
Oct 10, 2012·Carbohydrate Polymers·Priscileila Colerato FerrariRaul Cesar Evangelista
Feb 28, 2013·Food Chemistry·K KonecsniM T Nickerson
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Jun 29, 2014·Odontology·Doris M CamposBrigitte Grosgogeat
Sep 25, 2017·Journal of Biomedical Materials Research. Part a·Quentin DenostLaurence Bordenave
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Nov 11, 2019·Polymers·Martha Gabriela Chuc-GamboaJulio San Román Del Barrio
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Jun 5, 2021·International Journal of Biological Macromolecules·Omeira IqbalZunaira Afzal
Nov 26, 2010·International Journal of Pharmaceutics·Hardik K ShahClive G Wilson

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