An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts

Journal of Biomedical Materials Research. Part a
Brooke L FarrugiaTim R Dargaville

Abstract

This study investigates the effect of well-defined poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) ABA linear block co-oligomers on the proliferation of human dermal fibroblasts. The co-oligomers assessed ranged in molecular weight (MW) from 1335 to 5208 Da and hydrophilic-lipophilic balance (HLB) from 5.9 to 16.6 by varying the number of both PDMS and PEG units. In general, it was found that co-oligomers of low MW or intermediate hydrophilicity significantly reduced fibroblast proliferation. A linear relationship between down-regulation of fibroblast proliferation, and the ratio HLB/MW was observed at concentrations of 0.1 and 1.0 wt % of the oligomers. This enabled the structures with highest efficiency to be determined. These results suggest the possible use of the PEG-PDMS-PEG block co-oligomers as an alternative to silicone gels for hypertrophic scar remediation.

References

Feb 1, 1995·Journal of Biomedical Materials Research·D GranchiA Pizzoferrato
Dec 1, 1995·The Journal of Surgical Research·C C ChangS H Jee
Apr 8, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R E Fitzpatrick
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexander V KabanovValery Yu Alakhov
Nov 26, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jason ZastreHelen Burt
Dec 20, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Samir Mitragotri
Apr 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·M P LutolfJ A Hubbell
Jun 29, 2005·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Mar 1, 2006·Expert Opinion on Emerging Drugs·Karen Meier, Lillian B Nanney
Apr 9, 2008·Biotechnology and Bioengineering·Anne GigoutMario Jolicoeur
Jul 22, 2010·Angewandte Chemie·Katrin KnopUlrich S Schubert
Aug 21, 2010·Journal of Biomedical Materials Research. Part a·Emily C LynamZee Upton
May 14, 2011·Macromolecular Rapid Communications·Kristian KempeUlrich S Schubert

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