Jul 1, 1977

An investigation into the immunochemical properties of the isoenzymes of human alkaline phosphatase

Annals of Clinical Biochemistry
J S Abdullah, E Gowland

Abstract

A study was carried out to investigate the immunochemical properties of the alkaline phosphatases present in liver, placenta, intestine, and kidney. Butanol extracts of the tissues were examined by antigen-antibody crossed electrophoresis, and the immunoprecipitates formed by the enzymes were identified by use of a specific stain for alkaline phosphatase. The results obtained revealed three immuno-chemical types of alkaline phosphatase, designated L, P, and PI respectively. The distribution of these enzymes among the tissues examined was as follows: type L was the only enzyme detected in liver extract and type P the only one detected in placental extract. The extracts of intestine and kidney both contained two isoenzymes, one of which was type L and the other type PI.

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Mentioned in this Paper

Immunoelectrophoresis
Butanols
Enzymes, antithrombotic
Placenta Specimen
Tissue Specificity
Alkaline Phosphatase Measurement
Placenta
1-Butanol
Cross Reactions
Alkaline Phosphatase

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