PMID: 7537589Feb 1, 1995Paper

An investigation into the mechanism of capsaicin-induced oedema in rabbit skin

British Journal of Pharmacology
P Newbold, S D Brain

Abstract

1. Oedema formation induced by intradermal capsaicin has been studied in rabbit skin. The effect of the anti-inflammatory steroid dexamethasone and also of a range of known inhibitors of oedema formation have been investigated in order to elucidate mechanisms involved in capsaicin-induced oedema formation. 2. Oedema formation, in response to intradermally-injected test agents, was measured by the local extravascular accumulation of intravenously injected 125I-labelled albumin. In separate experiments skin blood flow was assessed by the clearance of intradermally-injected 133xenon. 3. Oedema formation induced by intradermal histamine (3 nmol) and bradykinin (1 nmol), when in the presence of vasodilator doses of calcitonin gene-related peptide (CGRP) (3 pmol) or prostaglandin E1, (PGE1) (10 pmol), was significantly inhibited (P < 0.01) in rabbits pretreated with intravenous dexamethasone (3 mg kg-1, -4 h). In contrast dexamethasone had no effect on capsaicin (3 mumol)-induced oedema formation or, on capsaicin (30-100 nmol)-induced blood flow. 4. Oedema formation observed in response to intradermal capsaicin (3 mumol) was significantly inhibited (P < 0.01) when the selective capsaicin antagonist, ruthenium red (3 nmol) was co-inje...Continue Reading

References

Mar 1, 1979·British Journal of Pharmacology·T J Williams
Jan 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L SautebinM Di Rosa
Feb 1, 1992·The British Journal of Dermatology·J Wallengren, R Håkanson
Sep 4, 1992·European Journal of Pharmacology·S R HughesS D Brain
Sep 1, 1992·Agents and Actions·R G RobertsR Payne
Jul 1, 1992·British Journal of Pharmacology·A AhluwaliaR J Flower
Apr 10, 1991·European Journal of Pharmacology·S H Peers, R J Flower
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C GarretP M Laduron
Sep 4, 1991·European Journal of Pharmacology·C M Hogaboam, J L Wallace
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G CirinoR B Pepinsky
Feb 1, 1985·Acta Physiologica Scandinavica·J BjörkK E Arfors
Dec 1, 1993·Trends in Pharmacological Sciences·P J Barnes, I Adcock
May 1, 1993·British Journal of Pharmacology·S M MoussaouiC Garret
Sep 1, 1994·Journal of Pharmacological and Toxicological Methods·S HughesT Williams
Jan 1, 1993·Agents and Actions·A Ahluwalia, R J Flower

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Citations

Feb 26, 2016·Burns : Journal of the International Society for Burn Injuries·Matthew K McIntyreDavid M Burmeister
May 14, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·James J DonkinRobert Vink
Jun 21, 2007·British Journal of Clinical Pharmacology·B J Van der SchuerenS R Sinclair
May 1, 2015·Critical Care : the Official Journal of the Critical Care Forum·Leonardo LorenteAlejandro Jiménez
Sep 13, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael R Halstead, Romergryko G Geocadin
Nov 22, 2017·PLoS Neglected Tropical Diseases·Luciana Lyra Casais-E-Silva, Catarina Teixeira
Nov 6, 2014·Biomolecular Concepts·Takenori Onaga
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jonathan FieldFrederik Claeyssens

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