An investigation into the range dependence of target delineation strategies for stereotactic lung radiotherapy

Radiation Oncology
Dennis J MohattHarish K Malhotra

Abstract

The "gold standard" approach for defining an internal target volume (ITV) is using 10 gross tumor volume (GTV) phases delineated over the course of one respiratory cycle. However, different sites have adopted several alternative techniques which compress all temporal information into one CT image set to optimize work flow efficiency. The purpose of this study is to evaluate alternative target segmentation strategies with respect to the 10 phase gold standard. A Quasar respiratory motion phantom was employed to simulate lung tumor movement. Utilizing 4DCT imaging, a gold standard ITV was created by merging 10 GTV time resolved image sets. Four alternative planed ITV's were compared using free breathing (FB), average intensity projection (AIP), maximum image projection (MIP), and an augmented FB (FB-Aug) set where the ITV included structures from FB plus max-inhale/exhale image sets. Statistical analysis was performed using the Dice similarity coefficient (DSC). Seventeen patients previously treated for lung SBRT were also included in this retroactive study. PTV's derived from the FB image set are the least comparable with the 10 phase benchmark (DSC = 0.740-0.408). For phantom target motion greater than 1 cm, FB and AIP ITV deli...Continue Reading

References

Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Aaron M AllenJames M Balter
May 18, 2005·Medical Physics·Eike RietzelGeorge T Y Chen
Aug 23, 2005·International Journal of Radiation Oncology, Biology, Physics·René W M UnderbergSuresh Senan
Nov 23, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jeffrey D BradleyDivya Khullar
Jan 1, 1994·IEEE Transactions on Medical Imaging·A P ZijdenbosA C Palmer
Dec 6, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rebecca MuirheadSarah Muscat
Jan 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Kwangyoul ParkLech Papiez
Oct 1, 2010·Medical Physics·Stanley H BenedictFang-Fang Yin
Jan 25, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Richard SpeightDavid Thwaites

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