An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive-adhesive force balances

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Matthew D JonesRobert Price

Abstract

The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-carrier adhesion and performance, by comparing data relating to many different drug-carrier combinations. Four drugs and four carriers were employed, giving a total of 16 combinations. The relative magnitude of the drug-carrier adhesion for each combination was quantified using the cohesion-adhesion balance (CAB) approach to colloidal probe atomic force microscopy. The in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-ca...Continue Reading

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Citations

Sep 29, 2009·Pharmaceutical Research·Chonladda PitchayajittipongRobert Price
Apr 6, 2012·Pharmaceutical Research·Waseem KaialyAli Nokhodchi
Jan 28, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Liqun JiangJiabi Zhu
Jan 10, 2014·Drug Delivery·Teerarat Rattanupatam, Teerapol Srichana
May 25, 2012·Journal of Pharmaceutical Sciences·Nashwa El-GendyCory Berkland
Mar 17, 2010·Journal of Pharmaceutical Sciences·Zhen XuAnthony J Hickey
Nov 30, 2011·Advanced Drug Delivery Reviews·Xiang KouPaul W S Heng
Nov 29, 2011·Advanced Drug Delivery Reviews·Jagdeep Shur, Robert Price
Oct 18, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wunlapa MueannoomSimon Gaisford
May 28, 2011·Advanced Drug Delivery Reviews·Gabrielle PilcerKarim Amighi
Apr 14, 2010·International Journal of Pharmaceutics·Simon GaisfordMatthew D Jones
Mar 10, 2010·International Journal of Pharmaceutics·Matthew D JonesGraham Buckton
Jan 27, 2010·International Journal of Pharmaceutics·Chonladda PitchayajittipongStephen Edge
Aug 26, 2015·International Journal of Pharmaceutics·Cordula WeissHelen Cathcart
Nov 14, 2013·Pharmaceutical Development and Technology·Jaleh VarshosazMahboubeh Rostami
Feb 26, 2013·International Journal of Pharmaceutics·Sara JaffariDarragh Murnane
Oct 10, 2012·Carbohydrate Polymers·Grazielle Arantes SoaresRaul C Evangelista
Aug 9, 2016·International Journal of Pharmaceutics·Xiang KouM Teresa Carvajal
Aug 23, 2017·Expert Opinion on Drug Delivery·Andrea Della BellaRuggero Bettini
Jun 3, 2017·Drug Development and Industrial Pharmacy·Saurabh SarkarBodhisattwa Chaudhuri
Jan 15, 2020·Drug Delivery and Translational Research·Mickey Socrates Ferdynand, Ali Nokhodchi
Dec 17, 2017·Journal of Pharmaceutical Sciences·Martin W JetzerGeorgios Imanidis
Nov 8, 2014·Molecular Pharmaceutics·Vasuki RamachandranKlimentina Pencheva

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