An investigation into the role of prostaglandins in zebrafish oocyte maturation and ovulation

General and Comparative Endocrinology
Andrea L Lister, G Van der Kraak

Abstract

This study explored the potential for ovarian-derived prostaglandins (PGs) to be involved in the regulation of oocyte maturation and ovulation in zebrafish. It was demonstrated that cultured vitellogenic follicles have the capacity to produce prostaglandin E(2) (PGE(2)) and PGF(2alpha) in response to arachidonic acid (AA) in a concentration-dependent manner, and that AA stimulates the in vitro production of 17beta-estradiol (E(2)). The production of AA-stimulated PGF(2alpha) was significantly reduced by treatment with the non-selective cyclooxygenase (COX) inhibitor, indomethacin (INDO). Treatment of full-grown follicles with AA did not induce oocyte maturation as assessed by germinal vesicle breakdown, but INDO significantly decreased the rate of spontaneous maturation. Using Real-Time PCR, it was shown that follicles of different developmental size classes (primary growth and pre-vitellogenic, early-vitellogenic, and mid- to full-grown vitellogenic) express enzymes that release (cytosolic phospholipase A(2) (cPLA(2)); phospholipase Cgamma1) or metabolize (COX-1, COX-2, and prostaglandin synthase-2) AA to PG metabolites. The expression of cPLA(2) was found to be significantly greater in full-grown follicles compared to follicl...Continue Reading

References

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Citations

Mar 22, 2014·Aquatic Toxicology·Jian HanBingsheng Zhou
Feb 28, 2013·Zygote : the Biology of Gametes and Early Embryos·Maria Eugenia OrtizLiliana Isabel Zelarayán
Feb 15, 2011·Annual Review of Physiology·Heiko Löhr, Matthias Hammerschmidt
Sep 2, 2014·Prostaglandins & Other Lipid Mediators·Simona ZariniMiguel A Gijón
Dec 19, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jane E MorthorstGlen Van Der Kraak
Jun 5, 2012·Molecular and Cellular Endocrinology·Chika FujimoriTakayuki Takahashi
May 24, 2012·General and Comparative Endocrinology·Amy H Y KwokFrederick C Leung
Nov 30, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Khageshor Bhandari, Barney Venables
May 4, 2010·General and Comparative Endocrinology·Sharon N Nelson, Glen Van Der Kraak
Apr 7, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anne JørgensenHenrik Leffers
Jun 16, 2009·General and Comparative Endocrinology·Jasvinder K DhillonZhiming Liu
Apr 16, 2009·General and Comparative Endocrinology·Sarah L Alderman, Nicholas J Bernier
May 2, 2009·Molecular and Cellular Endocrinology·Eric Clelland, Chun Peng
Jun 25, 2009·Molecular Reproduction and Development·Andrea L Lister, Glen J Van Der Kraak
Jan 24, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Byung Chul JeeSeok Hyun Kim
May 7, 2015·Critical Reviews in Toxicology·Matthew D OverturfDouglas A Holdway
Jun 26, 2014·Zygote : the Biology of Gametes and Early Embryos·Maria Eugenia OrtizLiliana Isabel Zelarayán
Jan 13, 2015·General and Comparative Endocrinology·Olivia M Knight, Glen Van Der Kraak
Feb 16, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dalma Martinovic-WeigeltDaniel L Villeneuve
Mar 17, 2010·Critical Reviews in Toxicology·Jenna CorcoranCharles R Tyler
May 26, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tegan A WilliamsNicholas J Bernier
Apr 10, 2020·Molecular Reproduction and Development·Masoumeh KhajehReza Rahbarghazi
Jun 3, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Shan HeQi-Wei Wei
Jul 28, 2019·General and Comparative Endocrinology·Sheridan J C Baker, Glen Van Der Kraak

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