An investigation into the type of beta-adrenoceptor mediating sympathetically activated renin release in the cat

British Journal of Pharmacology
E J Johns

Abstract

1 Stimulation of the renal nerves in the cat was previously shown to cause renin release which could be blocked by propranolol. An attempt was made in this study to determine the type of beta-adrenoceptor mediating this response.2 In anaesthetized, unilaterally nephrectomized cats, a comparison was made of the ability of two selective beta-adrenoceptor antagonists to block the tachycardia and hypotension caused by isoprenaline (mediated respectively by beta(1)- and beta(2)-adrenoceptors) and the release of renin caused by renal nerve stimulation.3 Isoprenaline (mean dose of 0.224 +/- 0.022 nmol/kg), increased heart rate by approximately 43 beats/min and decreased mean blood pressure by 47 mmHg. Stimulation of the distal cut ends of the renal nerves, at a rate sufficient to reduce renal blood flow by 30%, resulted in an approximately 150% increase in plasma renin activity.4 Administration of the selective beta(1)-adrenoceptor antagonist, atenolol (0.38 to 11.28 mumol/kg), caused a dose-related inhibition of nerve stimulated renin release and of isoprenaline-induced tachycardia, with no diminution of the vasodepressor response to isoprenaline; in contrast, the selective beta(2)-adrenoceptor antagonist, erythro-DL-(7-methylindan-4...Continue Reading

References

Jan 1, 1978·Annual Review of Physiology·I A ReidW F Ganong
Jan 1, 1976·Physiological Reviews·J O Davis, R H Freeman
Dec 1, 1974·The Journal of Clinical Investigation·M A WeberJ M Gain
Sep 1, 1980·Pflügers Archiv : European journal of physiology·U KoppB Ablad

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Citations

Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·I F Hesse, E J Johns
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·I M McKenzieJ K McKenzie
Oct 17, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Shoko TazumiKeiko Morimoto
Feb 1, 1994·The American Journal of Physiology·A Nakamura, E J Johns

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