An investigation into the use of thermorheology and texture analysis in the evaluation of W/O creams stabilized with a silicone emulsifier

Pharmaceutical Development and Technology
S TamburicJ Milić

Abstract

The aim of the study was to evaluate a range of W/O semisolid emulsion systems (creams) containing white soft paraffin (petrolatum) and a new type of nonionic lipophilic silicone emulsifier (Abil EM 90) using a novel combination of rheological tests. Emulsifier concentrations from 1.5% to 3.0% w/w were used with two manufacturing procedures, cold (25 degrees C) and warm (70 degrees C) emulsification, to determine whether and to what extent these variables alter the structure and consistency of the creams. The techniques comprised linear (continuous flow) and dynamic (oscillatory) rheometry at 25 degrees C, thermal flow experiments (from 10 degrees to 90 degrees C and back to 10 degrees C), and penetrometry studies. The differences in emulsifier concentration produced effects on the rheological properties of the W/ O creams, although the manufacturing process was much more influential. Cold emulsification led to creams with higher viscosity, lower thixotropy, and better elastic properties. The results of penetration tests on creams correlated with those of the rheological studies. The flow properties of white soft paraffin at 25 degrees C were comparable with the creams obtained by cold emulsification, while the elasticity was c...Continue Reading

References

Apr 1, 1969·Journal of Pharmaceutical Sciences·S S Davis
Jun 1, 1994·Pharmaceutical Research·L E PenaJ F Stearns
Sep 1, 1971·Journal of Texture Studies·B W Barry, A J Grace

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Citations

Jul 7, 2011·Expert Opinion on Drug Delivery·Tao YuGavin P Andrews
Feb 28, 2008·Drug Development and Industrial Pharmacy·Preetanshu Pandey, Gary D Ewing
Dec 28, 1999·Drug Development and Industrial Pharmacy·I BaquerizoM A Ruiz
Jun 29, 2007·International Journal of Pharmaceutics·Stefano SalmasoPaolo Caliceti
Feb 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tommasina CovielloMario Grassi
Apr 13, 2007·European Biophysics Journal : EBJ·C SandoloF Alhaique
Jan 1, 2009·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Dirk van Kampen
Mar 1, 2014·International Journal of Cosmetic Science·A TaiJ Jachowicz

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