An investigation of adequate volume for the diagnosis of malignancy in pleural fluids

Cytopathology : Official Journal of the British Society for Clinical Cytology
S C ThomasM E McKean

Abstract

The cytological examination of pleural effusions is an important investigation in the diagnosis of malignancy. Maximizing the chances of identifying malignant effusions is therefore desirable. Recent Royal College of Pathologists guidelines, based on the British Society for Clinical Cytology codes of practice, have suggested that a minimum of 20 ml of pleural fluid is required for diagnostic purposes. We examined 2155 pleural fluids received over a 6-year period in order to define a minimum required volume for adequacy. By examining the plateau phase of a graph of threshold volumes for initial samples received for each patient (n =1584) we determine that a minimum fluid volume of 25 ml is required and that more than 50 ml does not improve sensitivity. Between 25 and 50 ml of fluid are required for the adequate assessment of pleural effusions for malignancy.

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Citations

Jan 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·José M PorcelPyng Lee
Jun 17, 2011·Future Oncology·Krishna B SriramKwun M Fong
Dec 30, 2015·American Journal of Clinical Pathology·Lisa M RooperMatthew T Olson
Sep 16, 2015·Annales de pathologie·Monique Courtade-SaïdiUNKNOWN Sous l’égide de la Société française de cytologie clinique (SFCC)
Mar 1, 2017·The Clinical Respiratory Journal·Marios E FroudarakisPhilippe Astoul
Jul 29, 2018·The European Respiratory Journal·Anna C BibbyNick A Maskell
Jun 12, 2020·American Journal of Clinical Pathology·Erika F RodriguezZahra Maleki
Feb 13, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Erika F RodriguezMauro Saieg
Jul 31, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Anna C BibbyGiuseppe Cardillo
Jul 16, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Ediel ValerioMauro Saieg
Oct 31, 2020·Diagnostic Cytopathology·Hamza N GokozanClaire W Michael

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