PMID: 107632Mar 1, 1979

An investigation of allograft tolerance: Discordant reactivity to murine H-Y-incompatible lymphoid cell (PEC) and skin grafts

Transplantation
G HaughtonC J Wikstrand

Abstract

The extremely sensitive peritoneal exudate cell (PEC) transfer technique has been applied to an investigation of the immune response of female mice which are "tolerant" of the male antigen. Females rendered tolerant of male skin grafts by multiparity, neonatal inoculation of male spleen cells, or multiple inoculations of adult females with male lymphoid cells displayed second-set reactivity to male PEC while continuing to tolerate H-Y-incompatible skin grafts. Furthermore, this discordant response to male PEC and skin was adoptively transferrable to normal females by spleen cells from multiparous donors. Females rendered tolerant by irradiation and reconstitution with male cells were unresponsive to both H-Y-incompatible skin and PEC grafts. A model is proposed using two male-specific antigens, the response to which is controlled by independent genes.

Related Concepts

Peritoneal Fluid (Body Substance)
Ir Genes
SD Antigens
Natural Immunosuppression
Lymphoid Cells
Primiparity
Spleen
Transplantation, Autologous
Transplantation, Homologous
Skin Transplantation

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