An investigation of konjac glucomannan-keratin hydrogel scaffold loaded with Avena sativa extracts for diabetic wound healing

Colloids and Surfaces. B, Biointerfaces
Praveen Krishna VeerasubramanianVignesh Muthuvijayan

Abstract

We have developed a novel hydrogel composed of konjac glucomannan (KGM), human hair proteins (KER), and an ethanolic extract of Avena sativa (OAT) and evaluated its potential as a dressing material for diabetic wounds. KGM is an excellent biocompatible gelling agent that stimulates fibroblast proliferation and immunomodulation. Human hair proteins (KER) are biocompatible, biodegradable, and possess abundant cell adhesion sites. KER also promotes fibroblast attachment and proliferation, keratinocyte migration, and collagen expression, which can accelerate wound healing. OAT consists of oat β-glucans and several anti-inflammatory and antioxidant moieties that can reduce prolonged inflammation in chronic wounds. SEM images confirm the highly porous architecture of the scaffolds. When immersed in PBS, KGM + KER + OAT hydrogels absorb 7.5 times their dry weight. These hydrogels display a measured rate of degradation in lysozyme. KGM + KER + OAT hydrogels showed no significant cytotoxicity against NIH/3T3 fibroblasts. DAPI and SEM images obtained after 48 h of cell culture illustrate the attachment and infiltration of fibroblasts. In vivo studies performed using a diabetic rat excision wound model showed that KGM + KER + OAT hydrogel...Continue Reading

Citations

Mar 23, 2019·Molecular Nutrition & Food Research·Haihong ChenShaoping Nie
Jul 13, 2019·Journal of Biomedical Materials Research. Part a·Bożena TyliszczakJosef Jampilek
Aug 11, 2020·Macromolecular Rapid Communications·Huei Min ChuaKee Woei Ng
Nov 13, 2019·Phytotherapy Research : PTR·Tatiane Roquete AmparoGustavo Henrique Bianco de Souza
Jul 8, 2020·Materials·Alexandra Elena StoicaAlexandru Mihai Grumezescu
Dec 17, 2018·Carbohydrate Polymers·Itzel Rubio-ElizaldeAna B Castro-Ceseña
Nov 13, 2019·International Journal of Biological Macromolecules·Rania El HosaryAmany A Sleem
Apr 24, 2020·Bioactive Materials·Sandleen FerozGeorge Dias
Oct 5, 2020·International Journal of Biological Macromolecules·Pallavi Shyam KaparekarSuresh Kumar Anandasadagopan
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marek KonopJoanna Czuwara
May 29, 2021·Tissue Engineering and Regenerative Medicine·Vyshnavi TallapaneniVeera Venkata Satyanarayana Reddy Karri
Aug 31, 2021·Colloids and Surfaces. B, Biointerfaces·Yuan-Ning ZhangXiangdong Kong

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